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Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Intracellular Microlasers Could Allow Precise Labeling of up to a Trillion Individual Cells
MGH investigators have induced structures incorporated within individual cells to produce laser light at wavelengths that differ based on the size, shape and composition of each microlaser, allowing precise labeling of individual cells.
Real-Time Imaging of Lung Lesions During Surgery
Targeted molecular agents cause lung adenocarcinomas to fluoresce during surgery, according to pilot report.
Watching a Tumour Grow in Real-Time
Researchers from the University of Freiburg have gained new insight into the phases of breast cancer growth.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
New Vaccine For Chlamydia to Use Synthetic Biology
Prokarium Ltd, a biotechnology company developing transformational oral vaccines, have announced new funding from SynbiCITE, the UK’s Innovation and Knowledge Centre for Synthetic Biology.
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Next-Generation Data Storage
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Quantum Corp.

The explosion in life sciences data in general, and next-generation sequencing in particular, is nothing short of remarkable. At the 2010 Bio-IT World Expo, the director of IT at a leading genome institute casually remarked that he had just ordered 1.1 petabytes of storage to try to cope with the extraordinary surge in data generation. This puts a premium on sophisticated IT solutions not only for storing data, with reliable and secure backup and retrieval systems. Organizing the data, much of which is generated and viewed once and once only, is a problem that will require more work in future. In this Briefing On supplement, we present a selection of stories published in the past 12-24 months that have examined the technologies that are both creating and solving the next-gen data deluge (“The DNA Data Deluge”).

Increasingly, the value of next-gen sequencing studies is being validated with the identification of rare disease genes in studies of small families (“Next- Generation Genome Sequencing Identifies Disease Genes”). It is possible that the arrival of third-generation sequencing solutions, such as that from Pacific Biosciences (“PacBio’s Eleven”), will reduce the intense need to store image data, but IT managers aren’t popping the champagne corks just yet. One of the most interesting trends in next-gen data management is the potential of “on demand”.

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