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The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
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Advantages of Moving Towards 3-D Scaffolds for Cell Culture
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Nanofiber Solutions

As a biologist, little thought is given to the materials which make up the products that we use in our research day-in and day-out. However, it is these materials which form the ‘building block’ or‘scaffold’ of all cell culture research. The intricate detail going into understanding the cellular response is all dependent on the topographical patterns and surface chemistry of the scaffold used to grow these precious cells. Countless studies have shown the importance of choosing the appropriate tissue culture scaffolds: one that mimics the nanofibrous nature of the extracellular matrix for a wide variety of applications including basic cell biology, drug discovery,tissue engineering, cell migration and invasion, and stem cell expansion and differentiation. Cell culture is mainly performed on tissue culture polystyrene (TCPS) multiwell plates as it is cheap,optically clear, and many cells grow well on it. In reality, however, living organisms are made up of an extracellular matrix that presents both aligned physical structure and support to the cells.

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