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Monday, April 21, 2014
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Webcasts
Worried about your cell-based assays? Remote monitoring with CNS offers complete peace of mind!
Michael Fejtl, Market Manager, Tecan Austria
Microengineered Devices for Single Cell Analysis in Preclinical and Clinical Research
Nancy Allbritton, University of North Carolina, speaking at Single Cell Analysis Summit 2013.

Market Reports
Stem Cell Research
Stem Cell Research

This report on Stem Cell Research gives a market insight into the ever progressing and debatable market of Stem Cell Research segmented by type, technology and therapeutic area.
Stem Cell Research in Cardiology
RI Technologies

The report serves as a guide to global market for stem cells in cardiology covering more than 230 companies that are engaged in stem cell R&D, storage, banking, discovery, testing and supply of products and services.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities
Global Data

The report analyzes the role of biopharmaceutical products that basically provide enhancement to media, sera, reagents and cell culture market. Major manufacturing technologies involved in the cell culture technology have been detailed in the report. Furthermore, the report provides competitive benchmarking for the leading players that shape the global media, sera, reagent and overall cell culture market.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd

This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Stem Cells in Research & Drug Discovery Trends 2012
HTStec

This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on stem cells in research and drug discovery carried out in November 2012.
Stem Cell Research
RI Technologies

This report on Stem Cell Research gives a market insight into the ever progressing and debatable market of Stem Cell Research segmented by type, technology and therapeutic area.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Scientific News
How a Silly Putty Ingredient Could Advance Stem Cell Therapies
The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become.
Too Much Protein May Kill Brain Cells As Parkinson’s Progresses
NIH-funded study on key Parkinson’s gene finds a possible new target for monitoring the disease.
Bone Marrow Stem Cells Show Promise in Stroke Treatment, UCI Team Finds
Research analysis reveals that the stem cells trigger repair mechanisms, limit inflammation.
Light-activated Neurons Restore Function to Paralyzed Muscles
Scientists develop a new way to artificially control muscles using light.
Stem Cell-Derived Beta Cells Under Skin Replace Insulin
Research suggests that hESC-derived insulin-producing cells may be an effective and safe cell replacement therapy.
Cancer Biologists Link Tumor Suppressor Gene to Stem Cells
The findings appear online in the journal eLife.
Stem Cells Created from a Drop of Blood
The DIY finger-prick technique developed by scientists from A*STAR opens door for extensive stem cell banking.
Capturing Leukemic Stem Cells: A Major Breakthrough in Developing New Cancer Drugs
Important advance opens the way to the identification of new cancer drugs to fight acute myeloid leukemia, one of the most aggressive forms of blood cancer.
Stem Cell Study Opens Door to Undiscovered World of Biology
Discovery published in Nature measures protein production.
Researchers Generate New Neurons in Brains, Spinal Cords of Mammals
Researchers created new nerve cells without the need of stem cell transplants.
Business News
ReNeuron Signs Agreement with Welsh Government to Lease Facility
Agreement to lease a new R&D, manufacturing and headquarters facility in South Wales.
Merck Millipore Announces Incoming CEO and President
Udit Batra, Ph.D. will be responsible for the organization’s strategic direction to drive growth and product innovation as well as oversight of the worldwide operations.
BioLineRx Announces Investigator-Initiated Study for Novel CML Treatment
Phase 1/2 study will assess effect of BL-8040 in combination with standard therapy.
American CryoStem, Rutgers File Joint Patent
Combined technologies create basis for joint development of multi-functional nanotechnology platforms.
PAXgene® Blood DNA Tube CE Enables Global PT Scheme
Global Proficiency Testing scheme for DNA extraction from whole blood enabled for the first time.
Mallinckrodt Pharmaceuticals to Acquire Questcor for $5.6B
Combined company expected to deliver sustainable growth built on a more diversified product platform of novel therapeutics.
Faster Visa Endorsement will Support International Mobility for Top Researchers
This visa route is designed for the brightest and best bringing them from outside the European Economic Area to the UK.
SCT to Provide Update on CD47 Program at the 2014 AACR Annual Meeting
Announcing a key difference between SIRPaFc and other CD47-blocking agents.
ReNeuron Receives UK Regulatory Approvals
Company receive approvals to commence Phase II clinical trial in stroke and Phase I clinical trial in critical limb ischaemia.
Spark Therapeutics and Genable Technologies Announce Collaboration
Collaboration to advance a gene therapy treatment for a rare form of retinitis pigmentosa.

Events
Clinical Translation of Stem C
21 Apr 2014
Clinical Translation of Stem C ...
Stem Cell Summit 2014 
23 Apr 2014
Stem Cell Summit 2014  ...
Stem Cell Research & Regenerat
23 Apr 2014
Stem Cell Research & Regenerat ...
Stem Cell Commercialization &
23 Apr 2014
Stem Cell Commercialization & ...

ePosters
Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
TTP Labtech

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.
Integrating compound storage into automated laboratory workflows
TTP Labtech

This poster discusses the benefits of comPOUND for automated sample storage and delivery. TTP Labtech’s pneumatic transport technology, lab2lab, integrates these stores with other instrumentation into managed, fully automated workflows, allowing the scientist to focus on research and data analysis.
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech
Chang Gung University

Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech
Low cost, low footprint, expandable automated biobanking solutions
TTP Labtech, Abcam

This case study describes how TTP Labtech’s comPOUND storage modules have been employed by Abcam, a worldwide supplier of antibodies. Here, the turnaround time of sample placement and retrieval is an essential component for high quality service to its customers.
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.

Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
ISMTR-283 Protects Human Bone Marrow Progenitors from the Lethal Effects of Ionizing Radiation
ReachBio LLC

Bone Marrow (BM) is extremely susceptible to radiation damage. BM from matched donors is often used to ‘rescue’ patients following medical radiation for leukemia. However, in the event of accidental/environmental radiation exposure, the ability to identify appropriate donors in a timely manner is rarely possible. Using CFC assays, we evaluated a small molecule compound (ISMTR-283) for its potential to protect the marrow progenitor cells and microenvironment from radiation damage.
Analyzing Molecular Polar Surface Descriptors to Predict Blood-Brain Barrier Permeation
University of Würzburg

Permeation of active drugs across the vascular brain endothelium into the central nervous system (CNS) is controlled by the blood-brain barrier (BBB). Some molecular quantities like polar surface (PS) descriptors are of key interest to medicinal chemists to predict the BBB permeation fate for different drug-like chemical compounds.
The Mesenchymal Stem Cells Bioengineered Tissue Using Cobalt-60 Radiation
IPEN/CNEN - USP

The biological effects of gamma radiation by cobalt-60 sources on epidermal-dermal matrix have not been fully elucidated when mesenchymal stem cells cultured add in. This poster shows how scientists standardized the keratinocytes and adipose-derived stem cell (ADSC) culture procedure before constructing a bioengineered dermal-epidermal equivalent populated by keratinocytes and ADSC cultured cells.
Expression of Pluripotency-determining Factors in in vitro Fertilized Buffalo Embryos and Embryonic Stem Cells
Animal Biotechnology Centre, NDRI

The POU octamer-binding domain transcription factor Oct-4, Stage-specific embryonic antigens (SSEAs), and Tumor rejection antigens (TRAs), are developmentally regulated during early embryogenesis.
Effect of Culture Media and Serum Supplementation on the Development of in vitro Fertilized Buffalo Embryos
Central Institute for Research on Buffaloes

This poster compares the development of buffalo embryos in simple and complex culture media and aims to determine the effects of serum supplementation on the development of buffalo embryos.
Application Notes
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Stem cell research: Creating blood for high throughput screening
Tecan Group Ltd.

Many different research fields, including investigation of early human development processes, disease research, drug discovery and cellular therapy applications, require appropriate in vitro models which can accurately mimic in vivo processes to provide biologically relevant results. Pluripotent stem cells (PSCs) offer a powerful system for creating in vitro models to address these questions.
Analyzing Biological Samples
Tecan

This technical note describes the capability of Tecan’s Infinite® 200 PRO multimode reader to regulate the CO2 partial pressure inside its measurement chamber.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Sample Reformatting and Sample Archiving
FluidX

Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX

With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Isolation and Characterization of Human Bone-Marrow-Derived Mesenchymal Stem Cells
Millipore

Mesenchymal stem cells derived from bone marrow have become an attractive model cell system for the in vitro and in vivo study of disease states such as osteoporosis, obesity, and arthritis. We have isolated mesenchymal stem cells (MSCs) from the bone marrow aspirate of a single human donor. Human bone-marrow-derived MSCs express the mesenchymal stem cell markers STR0-1, CD44, and CD90, and do not express hematopoietic markers CD14 and CD19. Human bone-marrow-derived MSCs can be expanded for 18
Stem Cell-Derived Human Neurons in CNS Drug Discovery
Molecular Devices

Central nervous system (CNS) disorders affect many people worldwide. To increase the quality and number of drugs available for treatments of CNS disorders such as Alzheimer’s disease, schizophrenia and anxiety, the success rate of CNS drug discovery programs must be improved. The challenge in drug discovery is to develop more relevant assay systems to identify lead compounds for further development. Cell-based screening assays currently used for CNS drug discovery and development involve primary
Nucleofection® of mouse ES cells
Amaxa GMBH

Efficient delivery of DNA is crucial for gene targeting in embryonic stem cells and for successful generation of knock-out mice. Data presented in this technote show that Nucleofection® leads to a homogenous gene expression pattern in mouse ES cell colonies. In contrast to standard electroporation, Nucleofection® results in a 100% deletion of frt-flanked genes on both alleles. Viable and fertile mice were generated from transfected mouse ES cell clones.
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