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Wednesday, September 17, 2014
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Webcasts
Detection and Characterization of Viable Circulating Tumor Cells
Catherine Alix-Panabières, University Medical Center of Montpellier, speaking at Advances in Cellular Assays & Cell Culture 2014
A Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial Results
Qasim Rafiq, Loughbrough University, speaking at Advances in Cellular Assays & Cell Culture 2014

Market Reports
High Throughput Screening (HTS) Market by Technology, Applications, and End Users - Forecast to 2018
MarketsandMarkets

Technological advancements and flourishing outsourcing industry likely to propel the growth of the global high throughput screening market. In this report, the global high throughput screening market has been segmented on the basis of technology, products, applications, end users, and geography.
Academic Outreach & Non-Profit Screening Trends 2014
HTSTec

The main objectives of this global benchmarking study were to compile a report that comprehensively documents the current status, operational capabilities, interests, assay readouts, formats, funding, budgets, success criteria and future investments of academic and non-profit screening centers.
Stem Cell Research
Stem Cell Research

This report on Stem Cell Research gives a market insight into the ever progressing and debatable market of Stem Cell Research segmented by type, technology and therapeutic area.
Stem Cell Research in Cardiology
RI Technologies

The report serves as a guide to global market for stem cells in cardiology covering more than 230 companies that are engaged in stem cell R&D, storage, banking, discovery, testing and supply of products and services.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities
Global Data

The report analyzes the role of biopharmaceutical products that basically provide enhancement to media, sera, reagents and cell culture market. Major manufacturing technologies involved in the cell culture technology have been detailed in the report. Furthermore, the report provides competitive benchmarking for the leading players that shape the global media, sera, reagent and overall cell culture market.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd

This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Stem Cells in Research & Drug Discovery Trends 2012
HTStec

This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on stem cells in research and drug discovery carried out in November 2012.
Scientific News
Scientists Discover Neurochemical Imbalance in Schizophrenia
Researchers discovers that neurons from schizophrenia patients secrete higher amounts of three neurotransmitters.
Building Replacement Kidneys in the Lab
Milestone reached in work to build replacement kidneys in the lab.
Diabetes Researchers Find Faster Way to Create Insulin-producing Cells
A new protocol can turn stem cells into reliable, insulin-producing cells in about six weeks.
Wiping the Slate Clean
Erasing cellular memory and resetting human stem cells.
Combining Antibodies, Iron Nanoparticles and Magnets Steers Stem Cells to Injured Organs
Study published in nature communications details targeted nanomedicine therapy to regenerate heart muscle injured by heart attack.
Turning Human Skin Cells Into Immune-Fighting White Blood Cells
The fast and safe technique developed at the Salk Institute circumvents problems that have hindered regenerative medicine.
Clinical Trial to Test Safety of Stem Cell-Derived Therapy for Type 1 Diabetes
UC San Diego is initial site for first-in-human testing of implanted cell therapy.
In Directing Stem Cells, Context Matters
The surface cells are grown on has a profound effect on differentiation.
Banked Blood Grows Stiffer With Age
It may look like fresh blood and flow like fresh blood, but the longer blood is stored, the less it can carry oxygen into the tiny microcapillaries of the body.
Rare Stem Cells in Testis that Hold Potential for Infertility Treatments Identified
Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells — and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.
Business News
OncoCyte and Abcodia to Collaborate on Breast Cancer Diagnostic Development
PanC-Dx™ markers to be validated using pre-diagnosis patient serum samples exclusively provided by Abcodia.
Cellerant Awarded $47.5 Million Under Existing U.S. Government Contract
Additional funding to support planned phase 2 trial with CLT-008 in AML.
Center for Advanced Cellular Therapeutics to Rise on Penn Medicine Campus
New facility poised to accelerate the research and development of personalized cellular cancer therapies.
Stem Cell Agency Invests $16 million To Fight Diabetes
The California Institute for Regenerative Medicine (CIRM), California’s stem cell agency, today awarded $16 million to help accelerate the development of a treatment for type 1 diabetes.
ReNeuron Announces Appointment of Chief Executive Officer
Company appoints Olav Hellebø as new CEO.
ReNeuron AGM Trading Update
Results from the Phase I study with ReN009 announced in the first half of 2015.
Biomatrica Awarded $1 Million for US Army Million Soldier Ambient Temperature Biobank
The biobank will be the largest of its kind in the world.
Cellular Dynamics Awarded U.S. Patent
Patent strengthens CDI’s position as leading manufacturer of human cells for research and clinical applications.
DefiniGEN Joins European Bank for Induced Pluripotent Stem Cells (EBiSC) Consortium
EFPIA pharmaceutical companies, SMEs, and academia join together in an IMI supported public-private partnership project to establish the leading facility for the storage and distribution of induced pluripotent stem (iPS) cells in Europe.
Pharmaceutical Executive Joins Mesoblast as Chief Financial Officer
Appointment of Mr Paul Hodgkinson as Company’s Chief Financial Officer.

Events
Biology of Human Aging Confere
19 Sep 2014
Biology of Human Aging Confere ...
MipTec 2014 The Leading Europe
23 Sep 2014
MipTec 2014 The Leading Europe ...
2nd Annual Congress of the Eur
22 Sep 2014
2nd Annual Congress of the Eur ...
Fraunhofer Life Science Sympos
09 Oct 2014
Fraunhofer Life Science Sympos ...

ePosters
Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells: High Throughput and High Content Assessment of Cardiac Toxicity and Drug Efficacy by Monitoring Cytosolic Free Calcium Transients
1Axiogenesis AG, Cologne, Germany; 2Hamamatsu Photonics Deutschland GmbH, Hersching, Germany; 3Hamamatsu Photonics France S.A.R.L, Massy, France; 4Hamamatsu Photonics K.K., Hamamatsu City, Japan; 5Cel

Introduction of selected, pure human cardiomyocytes derived from induced pluripotent stem cell (hiPSCM) into a calcium transient imaging high throughput screening (HTS) assay to assess cardiotoxicity and drug efficacies.
Genetic integrity of rice seeds during ageing and gene bank storage by SSR analysis
Department of Plant Breeding and Seed Technology, Federal University of Agriculture, Abeokuta (FUNAAB), Nigeria.

Rice seeds loose germination capacity with ageing. Loses in genetic integrity was found to occur during artificial ageing at a time when percentage germination declined to 54%.
Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
TTP Labtech

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.
Integrating compound storage into automated laboratory workflows
TTP Labtech

This poster discusses the benefits of comPOUND for automated sample storage and delivery. TTP Labtech’s pneumatic transport technology, lab2lab, integrates these stores with other instrumentation into managed, fully automated workflows, allowing the scientist to focus on research and data analysis.
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech
Chang Gung University

Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech
Low cost, low footprint, expandable automated biobanking solutions
TTP Labtech, Abcam

This case study describes how TTP Labtech’s comPOUND storage modules have been employed by Abcam, a worldwide supplier of antibodies. Here, the turnaround time of sample placement and retrieval is an essential component for high quality service to its customers.
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.

Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
ISMTR-283 Protects Human Bone Marrow Progenitors from the Lethal Effects of Ionizing Radiation
ReachBio LLC

Bone Marrow (BM) is extremely susceptible to radiation damage. BM from matched donors is often used to ‘rescue’ patients following medical radiation for leukemia. However, in the event of accidental/environmental radiation exposure, the ability to identify appropriate donors in a timely manner is rarely possible. Using CFC assays, we evaluated a small molecule compound (ISMTR-283) for its potential to protect the marrow progenitor cells and microenvironment from radiation damage.
Analyzing Molecular Polar Surface Descriptors to Predict Blood-Brain Barrier Permeation
University of Würzburg

Permeation of active drugs across the vascular brain endothelium into the central nervous system (CNS) is controlled by the blood-brain barrier (BBB). Some molecular quantities like polar surface (PS) descriptors are of key interest to medicinal chemists to predict the BBB permeation fate for different drug-like chemical compounds.
The Mesenchymal Stem Cells Bioengineered Tissue Using Cobalt-60 Radiation
IPEN/CNEN - USP

The biological effects of gamma radiation by cobalt-60 sources on epidermal-dermal matrix have not been fully elucidated when mesenchymal stem cells cultured add in. This poster shows how scientists standardized the keratinocytes and adipose-derived stem cell (ADSC) culture procedure before constructing a bioengineered dermal-epidermal equivalent populated by keratinocytes and ADSC cultured cells.
Application Notes
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Stem cell research: Creating blood for high throughput screening
Tecan Group Ltd.

Many different research fields, including investigation of early human development processes, disease research, drug discovery and cellular therapy applications, require appropriate in vitro models which can accurately mimic in vivo processes to provide biologically relevant results. Pluripotent stem cells (PSCs) offer a powerful system for creating in vitro models to address these questions.
Analyzing Biological Samples
Tecan

This technical note describes the capability of Tecan’s Infinite® 200 PRO multimode reader to regulate the CO2 partial pressure inside its measurement chamber.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Sample Reformatting and Sample Archiving
FluidX

Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX

With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Isolation and Characterization of Human Bone-Marrow-Derived Mesenchymal Stem Cells
Millipore

Mesenchymal stem cells derived from bone marrow have become an attractive model cell system for the in vitro and in vivo study of disease states such as osteoporosis, obesity, and arthritis. We have isolated mesenchymal stem cells (MSCs) from the bone marrow aspirate of a single human donor. Human bone-marrow-derived MSCs express the mesenchymal stem cell markers STR0-1, CD44, and CD90, and do not express hematopoietic markers CD14 and CD19. Human bone-marrow-derived MSCs can be expanded for 18
Stem Cell-Derived Human Neurons in CNS Drug Discovery
Molecular Devices

Central nervous system (CNS) disorders affect many people worldwide. To increase the quality and number of drugs available for treatments of CNS disorders such as Alzheimer’s disease, schizophrenia and anxiety, the success rate of CNS drug discovery programs must be improved. The challenge in drug discovery is to develop more relevant assay systems to identify lead compounds for further development. Cell-based screening assays currently used for CNS drug discovery and development involve primary
Nucleofection® of mouse ES cells
Amaxa GMBH

Efficient delivery of DNA is crucial for gene targeting in embryonic stem cells and for successful generation of knock-out mice. Data presented in this technote show that Nucleofection® leads to a homogenous gene expression pattern in mouse ES cell colonies. In contrast to standard electroporation, Nucleofection® results in a 100% deletion of frt-flanked genes on both alleles. Viable and fertile mice were generated from transfected mouse ES cell clones.
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