Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

NIH-Funded Researchers Generate Mature Egg Cells From Early Ovarian Follicles

Published: Monday, August 09, 2010
Last Updated: Monday, August 09, 2010
Bookmark and Share
Technique successful in mice, may offer women new options for fertility treatment.

Researchers supported by the National Institutes of Health have for the first time activated mouse egg cells at the earliest stage of their development and brought them to maturity. In a related experiment, the researchers replicated the finding by also bringing human eggs to maturity in the laboratory.

Current infertility treatment techniques stimulate immature eggs so they develop to the stage at which the eggs can be fertilized, but these techniques work only on eggs at a comparatively late stage of development. These later-stage eggs are few in number and much more difficult to recover than the early-stage eggs used by the researchers in this study.

Using the new technique, the researchers brought dormant mouse eggs to full maturity within the laboratory. The eggs then were fertilized and transferred into female mice, which carried them to term.

The human eggs were not fertilized. The technique is still in its early stages, has not been sufficiently studied for human use and will require several more years of study.

According to the researchers, one day this technique could be used to treat female infertility, particularly forms of infertility in which the supply of available eggs is diminished or limited. Similarly, the technique could be combined with efforts to bank the ovarian tissue of women in need of cancer therapy that might cause infertility.

"The researchers have developed a promising new technique that may someday provide additional options for women seeking treatment for certain forms of infertility," said Alan E. Guttmacher, M.D., director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the NIH Institute that funded the study.

The findings appear online in the Proceedings of the National Academy of Sciences.

First author Jing Li conducted the research with Stanford University colleagues Yuan Cheng, Cynthia Klein and Aaron J.W. Hsueh; Kazuhiro Kawamura of Akita University; and Shuang Liu, Shu Liu and En-Kui Duan of the Chinese Academy of Sciences.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Gene Scan Finds Link Across Array of Childhood Brain Disorders
Researchers found gene mutations through whole exome sequencing - a new gene scanning technology that cuts the cost and time of searching for rare mutations.
Friday, August 27, 2010
NIH-Funded Researchers Make Progress Toward Regenerating Tissue to Replace Joints
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting edge process to form the joint inside the body, or in vivo.
Monday, August 02, 2010
Gene Associated with Rare Adrenal Disorder Appears to Trigger Cell Death, According to NIH Study
Mice lacking Prkar1a gene in the adrenal glands developed an overgrowth of adrenal tissue and tumors in the gland.
Thursday, July 15, 2010
NIH Opens Website for Human Embryonic Stem Cell Lines for Approval and Announces Members of Working Group
NIH is now accepting requests for human embryonic stem cell lines to be approved for use in NIH-funded research.
Thursday, October 08, 2009
Scientists Report Gene Network in Early Tooth Development
Researchers have deduced a network of dental genes in cichlids that likely was present to build the first tooth some half a billion years ago.
Wednesday, February 11, 2009
NIH Announces Plan to Implement President's Stem Cell Executive Order
The plan calls for aggressively pursuing an assessment of the potential of alternative sources of pluripotent stem cell lines.
Thursday, September 20, 2007
Researchers Isolate Adult Stem Cells for First Time in Tendon
The finding points to a natural source of tendon-producing cells in adults and raises the possibility that these cells one day could help to mend torn or degenerating tendons.
Tuesday, September 11, 2007
Unstable Leukemia Stem Cells may Predispose Patients to Drug Resistance
A NIH study shows that BCR-ABL gene in chronic myeloid leukemia stem cells can help explain the reason for resistance of patients to the drug imatinib that target that gene.
Wednesday, May 02, 2007
Scientific News
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
BioCision Forms MedCision
The new company will focus on technologies for the management and automation of vital clinical processes.
Defining Immortality of Stem Cells
Researchers defined the mechanisms underlying increased protein quality control of pluripotent stem cells.
Enhancing CRISPR to Explore Further
Researchers have developed sOPTiKO, a more efficient and controllable CRISPR genome editing platform.
Regenerating Diseased Hearts
Researchers from the University of Otago have probed the potential of adult stem cell types to repair diseased hearts.
Stem Cells Police Themselves to Reduce Scarring
Scientists have discovered stem cells in muscle fibers change gene expressions to respond to injury.
Bright Red Fluorescent Protein Created
Scientists have created a bright red, fluorescent protein that could be used to track essential cellular processes.
Protein Self-Regulates Abundance
Researchers have uncovered how a protein, that plays a crucial role in embryonic stem cell renewal, is regulated.
Topical Immunotherapy Effective Against Early Skin Cancer
Combination of two commonly used drugs triggers immune response against precancerous skin lesions.
Factors Behind Suppression of Stem Cell Mobilization Revealed
The findings could lead to improvements in transplantation therapy.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!