Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Discarded Immune Cells Induce the Relocation of Stem Cells

Published: Tuesday, May 28, 2013
Last Updated: Tuesday, May 28, 2013
Bookmark and Share
Scientists investigate the evolution and elimination of neutrophils.

Neutrophils are leukocytes (white blood cells) that defend the body against attack from bacteria and other disease organisms. To perform their function, these cells release toxic substances when they come into contact with microorganisms. However, release of these substances in the wrong place by damaged neutrophils can result in severe injury to blood vessels and tissues.

Evolution appears to have resolved this conflict by ensuring that neutrophils are renewed much more rapidly than most other cells in the body: approximately 1011 neutrophils are eliminated every day and an equivalent number of stem cells are released into the bloodstream. This in turn generates a second problem: what to do with all these cells that have to be eliminated.

Dr. Andrés Hidalgo and his team in the Department of Epidemiology, Atherosclerosis and Cardiovascular Imaging, led by Dr. Valentín Fuster, have discovered the function of these neutrophils expelled every day by the body.

Graduate student María Casanova Acebes (Universidad Autónoma de Madrid), found that when additional apoptotic neutrophils were injected into mice, there was an increase in the number of circulating hematopoietic stem cells, the cells that generate all blood cells.

Using a wide variety of experimental approaches, including imaging assays, pharmacological treatments and genetic analysis, the team showed that when neutrophils in the blood get old, they migrate to the bone marrow to be eliminated by specialized phagocytotic cells called macrophages. The act of phagocytosing the neutrophils alters these macrophages’ genetic properties and functions, and these changes in turn alter the function of specialized cells whose job it is to retain hematopoietic stem cells in the bone marrow. “As a consequence, the stem cells are released into the blood”, explains María Casanova, first author of the study.

According to Dr. Hidalgo, “Key questions that arise from our study relate to the role of the hematopoietic stems cells expelled from the bone marrow, and how the elimination of neutrophils might affect other important stem cell populations, for example those that produce tumors”.

The research also reveals that the aging of neutrophils follows a day/night, or circadian, cycle, suggesting possible implications for disease processes—for instance heart attack—that occur more frequently at certain times of day.

“Our study shows that stem cells are affected by day/night cycles thanks to this cell recycling. It is possible that the malign stem cells that cause cancer use this mechanism to relocate, for example during metastasis”, Hidalgo emphasizes.

But this finding could have more direct implications for cardiovascular health. According to the authors, the daily changes in the function of neutrophils could be responsible for the tendency of acute cardiovascular and inflammatory events, such as heart attack, sepsis or stroke, to occur at certain times of day.

Dr. Hidalgo concludes, “Given that this new discovery describes fundamental processes in the body that were unknown before, it will now be possible to interpret the alterations to certain physiological patterns that occur in many diseases.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Stem Cell Therapy Heals Injured Mouse Brain
A team of researchers has developed a therapeutic technique that dramatically increases the production of nerve cells in mice with stroke-induced brain damage.
Challenging Stem Cell Fate Control
Researchers have found that the fate of stem cells is not only controlled by their local niche, but also by a cell-intrinsic mechanism.
Zika Proteins Responsible for Microcephaly Identified
Researchers have undertaken the first study to examine Zika infection in human neural stem cells from second-trimester fetuses.
Heart Muscle from Stem Cells Aid Cardiovascular Medicine
Researchers discover heart muscle cells from stem cells mirror expression patterns of key genes in donor tissue.
Examining New Hypotheses for Undiagnosed Patients
UnDx Consortium gathers in San Diego to create new paths to identifying currently undiagnosed illnesses.
Novel Therapeutic Approach for Blood Disorders
Gene editing of human blood-forming stem cells mimics a benign genetic condition that helps to overcome sickle cell disease and other blood disorders.
Bone Marrow Transplants Without Using Chemotherapy
Scientists have devised a way to destroy blood stem cells in mice without using chemotherapy or radiotherapy, both of which have toxic side effects.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Two Zika Proteins Responsible For Microcephaly Identified
It’s the first study to examine Zika infection in human neural stem cells from second-trimester fetuses, USC researchers say.
Directly Reprogramming a Cell's Identity with Gene Editing
Duke engineers use CRISPR to generate neuronal cells from connective tissue.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!