Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Mouse Studies Show Gene Therapy Method Holds Promise in Targeting Tumor Blood Vessels for Destruction

Published: Thursday, December 18, 2008
Last Updated: Thursday, December 18, 2008
Bookmark and Share
Cancer researchers develop method for delivering a therapeutic gene specifically to the blood vessels of tumors in mice.

Cancer researchers have reported the development of a novel method for delivering a therapeutic gene specifically to the blood vessels of tumors in mice. Once delivered, the gene produces a protein that damages the blood vessels and disrupts the blood flow to tumors but not to the surrounding tissue.

These results obtained with this experimental model are encouraging, because the researchers' method may be safer and cause fewer side effects than previously used methods for delivering the protein to tumors.

The study, led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and The University of Texas M.D. Anderson Cancer Center in Houston, appearing in the January 1, 2009, issue of "Cancer".

Blood vessels supply tumors with oxygen and nutrients that they need to grow beyond a certain size. Tumor necrosis factor-alpha (TNF-a), a protein produced by immune cells, has been shown to inhibit the growth of tumors by causing damage to their blood vessels. Since TNF-a can also damage the blood vessels of noncancerous tissues, systemic administration of the protein through the bloodstream can cause severe side effects.

Currently, TNF-a is used to treat human melanomas and sarcomas in patients' limbs or organs by isolating the blood vessels that supply the limb or organ from the rest of the body's circulatory system. This treatment approach produces local toxicity but little systemic toxicity.

Since most tumors are located in other areas of the body where this therapeutic approach cannot be used, the research team, led by Steven K. Libutti, M.D., and Anita Tandle, Ph.D., of NCI's Center for Cancer Research, in collaboration with Renata Pasqualini, Ph.D., and Wadih Arap, M.D., of M.D. Anderson, developed a novel gene therapy method that allowed them to target the delivery of TNF-a to tumor blood vessels and avoid damage to noncancerous tissues.

In gene therapy, a vector, or delivery vehicle, is used to carry a gene to a target cell or tissue. Once the gene is delivered, it is turned on, or expressed, and a protein is produced. In their study, the research team found that a type of vector known as an adeno-associated virus phage (AAVP) could effectively deliver the "TNF-a" gene to the blood vessels of human melanoma tumors in mice. AAVP is a hybrid vector that is made from a bacterial virus, or bacteriophage, which normally infects only bacteria, and an adeno-associated virus, which infects humans and some other primate species.

Bacteriophage-based vectors have a long history of safe delivery to humans. The bacteriophage component was engineered to target and infect specific mammalian cells, namely tumor blood vessel cells, by modifying the bacterial virus' outer-surface protein. The adeno-associated virus component was used to facilitate "TNF-a" gene expression in the targeted cells.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

2011 Biospecimen Research Network (BRN) Symposium
The National Cancer Institute's (NCI) Biospecimen Research Network Symposium, "Advancing Cancer Research Through Biospecimen Science," will be held March 28-29, 2011, at the Bethesda North Marriott Hotel & Conference Center in Bethesda, MD
Friday, January 07, 2011
Scientists Identify Markers on Human Breast Cancer Cells Linked to Development of a Form of Breast Cancer
The scientists named these human cells with tumor-forming ability in mice, xenograft-initiating cells, or XIC.
Friday, May 21, 2010
Drug for Multiple Myeloma Demonstrated to Extend Disease-Free Survival
Patients receiving lenalidomide following a blood stem cell transplant had their cancer kept in check longer than placebo receiving patients.
Thursday, December 24, 2009
Cancer Immunotherapy Can Use Small Numbers of Stem-Like Immune Cells to Destroy Large Tumors in Mice
New approach to stimulating immune cells enhances their anticancer activity, resulting in a powerful anti-tumor response in mice.
Friday, June 26, 2009
Researchers Develop a Method to Evaluate Variations Identified in Breast Cancer Susceptibility Genes
The researchers believe that the new test could become a useful and viable tool for genetic counselors, and may have implications beyond cancer.
Tuesday, July 08, 2008
Method of Gene Therapy Alters Immune Cells for Treatment of Advanced Melanoma
Technique may also apply to other common cancers.
Friday, September 01, 2006
Scientific News
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Bile Acid Supports Production of Blood Stem Cells
A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.
New Biomarker to Assess Stem Cells Developed
A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Edited Stem Cells Offer Hope of Precision Therapy for Blindness
Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.
Hacking the Programs of Cancer Stem Cells
All tumor cells are the offspring of a single, aberrant cell, but they are not all alike.
Newfound Strength in Regenerative Medicine
A promising new approach uses direct mechanical stimulation to repair severely damaged skeletal muscles.
Mapping out Cell Conversion
Researchers develop algorithm that takes the field of cell reprogramming forward.
Donor's Genotype Controls the Differentiation of IPS Cells
Pluripotent stem cells derived from different cell types are equally susceptible to reprogramming, indicates a recent study by the University of Helsinki and the National Institute for Health and Welfare, Finland. However, the genotype of the donor strongly influences the differentiation of the stem cell.
Signals That Make Early Stem Cells Identified
Researchers at The Rockefeller University have identified a new mechanism by which cells are instructed during development to become stem cells
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!