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Sunday, December 21, 2014
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Analyzing Molecular Polar Surface Descriptors to Predict Blood-Brain Barrier Permeation
Sergey Shityakova, Winfried Neuhausa, Thomas Dandekarc and Carola Förstera

Permeation of active drugs across the vascular brain endothelium into the central nervous system (CNS) is controlled by the blood-brain barrier (BBB). Some molecular quantities like polar surface (PS) descriptors are of key interest to medicinal chemists to predict the BBB permeation fate for different drug-like chemical compounds.

The Mesenchymal Stem Cells Bioengineered Tissue Using Cobalt-60 Radiation
Mosca, RC., Isaac, C., Mathor, MB

The biological effects of gamma radiation by cobalt-60 sources on epidermal-dermal matrix have not been fully elucidated when mesenchymal stem cells cultured add in. This poster shows how scientists standardized the keratinocytes and adipose-derived stem cell (ADSC) culture procedure before constructing a bioengineered dermal-epidermal equivalent populated by keratinocytes and ADSC cultured cells.

Expression of Pluripotency-determining Factors in in vitro Fertilized Buffalo Embryos and Embryonic Stem Cells
T Anand, D Kumar, M S Chauhan, and P Palta

The POU octamer-binding domain transcription factor Oct-4, Stage-specific embryonic antigens (SSEAs), and Tumor rejection antigens (TRAs), are developmentally regulated during early embryogenesis.

Effect of Culture Media and Serum Supplementation on the Development of in vitro Fertilized Buffalo Embryos
D Kumar, T Anand, P Palta and M.S. Chauhan

This poster compares the development of buffalo embryos in simple and complex culture media and aims to determine the effects of serum supplementation on the development of buffalo embryos.

High Content Analysis of Neural Stem Cell Expansion and Differentiation
Oksana Sirenko, Allan C. Powe, Steven L. Stice, Karen Cook, Nick Callamaras, Jayne Hesley, Xin Jiang and Evan F. Cromwell

Automated assay methods for monitoring neural stem cell expansion and differentiation using stem cell derived neural cell lines and high content imaging systems have been described.

Neurotoxicity Assays Using iPSC-Derived Neurons and High Content Imaging
Oksana Sirenko, Susan DeLaura, Lucas Chase, Jayne Hesley and Evan F. Cromwell

Neurotoxicity can cause temporary or permanent damage of brain or peripheral nervous system and has been found to be a major cause of neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Accordingly, there is a great interest in developing more predictive, disease relevant cell-based models and efficient screening tools for assessing the neurotoxicity of chemical compounds, drug candidates and environmental agents.

Live Cell Beating Assay Using Human iPSC-derived Cardiomyocytes for Evaluation of Drug Efficacy and Toxicity
Oksana Sirenko, Carole Crittenden, Blake Anson, Jayne Hesley, Yen-Wen Chen, Nick Callamaras and Evan F. Cromwell

A large percentage of new drugs fail in clinical studies due to cardiac toxicity. Development of highly predictive in vitro assays suitable for screening, safety assessment or other environments is therefore extremely important for drug development. Human cardiomyocytes derived from stem cell sources can greatly accelerate the discovery of cardiac drugs and improve drug safety by offering more clinically relevant cell-based models than those presently available.

Regulation of shoot apical meristem development by SEUSS and SEUSS-LIKE 2 in Arabidopsis
Joanne E. Lee and John F. Golz

In Arabidopsis, SEU and SLK2 are redundant components of a regulatory complex that is proposed to promote shoot apical meristem (SAM) formation during embryogenesis. Expression analysis indicates that SEU and SLK2 act upstream of several known SAM regulators, and also regulate auxin accumulation, probably via interaction with auxin response factors.

Expansion of mesenchymal stem cells from frozen UCB
Christophe NP Madsen and Christian Clausen

Umbilical cord blood (UCB) has recently been the focus of clinical applications. UCB contains of hematopoietic stem cells and mesenchymal stem cells (MSC). Clinical studies shows that MSC can be used in regenerative medicine hereby treatment of cardiac diseases. The aim of this project is to establish a protocol for isolation of MSCs from frozen UCB. This study demonstrated that it’s possible to expand MSC.

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Showing Results 11 - 20 of 71
Scientific News
Stem Cells Faulty In Duchenne Muscular Dystrophy
In a mouse model of Duchenne muscular dystrophy, muscle stem cells express connective-tissue genes associated with fibrosis and muscle weakness, according to a new study.
Cutting Out the Cellular Middleman
New technology directly reprograms skin fibroblasts for a new role.
Proteins Drive Cancer Cells To Change States
When RNA-binding proteins are turned on, cancer cells get locked in a proliferative state.
Patient’s Own Stem Cells Could Clear a Cloudy Cornea
Researchers use patient’s own cells from the uninjured eye for this process.
Stem Cells from Adult Nose Tissue Used to Cure Parkinson’s Disease in Rats
Researchers produce mature neurons in the laboratory using inferior turbinate stem cells.
Protein Key To Harnessing Regenerative Power Of Blood Stem Cells Unlocked
Stem cells lacking the protein have an increased ability to replicate in the natural environment and following transplantation.
Genetic Errors Linked To Aging Underlie Leukemia That Develops After Cancer Treatment
New research by Daniel Link, MD, and colleagues at The Genome Institute at Washington University has revealed that mutations that accumulate randomly as a person ages can play a role in a fatal form of leukemia that develops after treatment for another cancer.
Stem Cells Can Be Activated To Help Immune System
UCLA researchers have discovered that the Scalloped and Yorkie genes play a key role in how progenitor stem cells are activated to fight infection.
Role of Cancer Stem Cells in Chemo-Resistance
'Wound response' of cancer stem cells may explain chemo-resistance in bladder cancer.
Discovering A New Mechanism For Sex Control In Zebrafish
Research shows that reduction of germ cells yields more males.
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