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Wednesday, July 30, 2014
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Superporous SIKVAV-modified PHEMA scaffold promotes stem cell adhesion
V.Vanecek, S.Kubinova, D.Horak, V.Proks, E.Sykova

Poly(2-hydroxyethyl methacrylate) (PHEMA) is successfully used as a scaffold material for tissue engineering; however, it lacks functional groups that support cell adhesion. The laminin-derived peptide sequence SIKVAV is known to mimic the function of laminin, which is one of the biologically active proteins of the extracellular matrix. In this report, the adhesion of mesenchymal stem cells (MSC) to SIKVAV-modified PHEMA was investigated.

The effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling
M. Kapcalova, M. Babic, P. Jendelova, V. Herynek, K. Likavcanova, D. Horak, M. Hajek, E. Sykova

Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Patricia Ap. Santiago; Claudio A Suazo; Roberto C Giordano.

In biochemical processes involving cultivation of animal cells, the supply of oxygen in culture medium is an extremely important parameter in the project of bioreactors and its operation. In this work, the global volumetric transfer coefficient of oxygen (KLa) is evaluated in a Taylor vortex flow bioreactor (TVFB) and a correlation of mass transfer, of this equipment, is proposed.

Reliable and Predictive In Vitro Assays for Myelotoxicity and Cardiotoxicity of Kinase Inhibitors
Clarke E (1), Schwengberg S (2), Kettenhofen R (2), Dos Santos G (1), Bohlen H (2)

Kinase inhibitors (KIs) represent a new class of rationally designed drugs. The success of Imatinib has prompted the development of other KIs for the treatment of various cancers and inflammation. Although more successful than conventional therapies, myelotoxicity and cardiotoxicity are often major side effects of KIs. In order to predict if newly developed molecules demonstrated significant myelotoxicity or cardiotoxicity, we assessed a number of TKIs using in vitro models.

Intra-operative Bone Marrow Processing for Bone Regeneration
E. Nedelcu MD, A. Jamali MD, L. Hill RN, J. Nolta PhD, D. Vierria RN, M. Hoze RN, D. Taylor MD PhD, C. Gresens MD, D. Dwyre MD

Concentrated stem cell products obtained from autologous bone marrow aspirate were previously shown to regenerate avascular necrosis of the bone and non-union fractures. The aspirate processing was performed using apheresis technology, however, a detailed protocol has not been published yet. The aim of our study was to develop a clinical protocol using the CobeSpectra apheresis device to process the bone marrow aspirate.

The Expression and Activity of MMPs during Zebrafish (Danio rerio) Development
N.D. Harris, D.H. Li, J.Y. Keow, C. Po, A. Hong, K. Herrmann, B.D. Crawford

Recent advances have made the zebrafish an attractive system for studying MMP activity. However, there are few commercially available antibodies against MMPs that are suitable for studies using zebrafish. The objectives of the study presented in the poster were to develop effective immunological reagents for the study of MMPs in zebrafish and to test commercially available narrow-spectrum fluorogenic MMPs substrates in in vivo zymography.

Genetic profile of human embryonic stem cells (hESC) grown under different O2 concentrations
Sonia Prado, David Montaner, Dario Melguizo,Rubén Moreno, Joaquín Dopazo and Miodrag Stojkovic.

The development of mammalian embryos during the early stages takes place in a hypoxic environment. After 11 weeks of pregnancy the mother’s blood begins to flow freely in the placental space increasing the partial pressure of oxygen [1-3]. Therefore, we hypothesized that in vitro growth of hESC in normoxic conditions (21% O2) may change the profile and differentiation potential of hESC.

Induced Pluripotency with Endogenous and Inducible Genes

The recent discovery that two partly overlapping sets of four genes induce nuclear reprogramming of mouse and human has opened up new possibilities for cell replacement therapies. Although the combination of genes that induce pluripotency to some extenet, Oct4 and Sox2 appear to be a prerequisite. The introduction of four genes, several of which have been linked with cancer, using retroviral approaches is however unlikely to be suitable for future clinical applications.

Human Fetal Bone Cells Seeded in Hyaluronic Acid Gel As A Delivery System For Bone Engineering
D.Tenorio, L.A.Applegate, S. Jaccoud, C.Scaletta, D.P. Pioletti

Human fetal bone cells seeded in a hyaluronic acid gel as a delivery system, can survive and proliferate within this gel, are positive for alkaline phosphatase and von Kossa staining, demonstrating the potential of these cells bone engineering.

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Showing Results 41 - 50 of 68
Scientific News
Stem Cells from Nerves Forming Teeth
Findings published in the scientific journal Nature.
Wisconsin Scientists Find Genetic Recipe to Turn Stem Cells to Blood
The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.
No Extra Mutations in Modified Stem Cells, Study Finds
New results ease previous concerns that gene-editing techniques-used to develop therapies for genetic diseases-could add unwanted mutations to stem cells.
Patient-Specific Stem Cells and Personalized Gene Therapy
Patients’ own cells transformed into model for studying disease and developing potential treatment.
Researchers Regrow Human Corneas
Limbal stem cells - identified with a new marker - could reverse a leading cause of blindness.
New Reprogramming Method Makes Better Stem Cells
Researchers have shown for the first time that stem cells created using different methods produce differing cells.
Scientists Identify Link Between Stem Cell Regulation and the Development of Lung Cancer
Study explains how factors that regulate the growth of adult stem cells lead to the formation of precancerous lesions.
CRI Finds Key to Identifying, Enriching Mesenchymal Stem Cells
Biomarker enables researchers to accurately characterize the properties and function of MSCs in the body.
Researchers Find Gene Critical for Development of Brain Motor Centre
The team describes the Snf2h gene, which is found in our brain's neural stem cells and functions as a master regulator.
Stem Cells Form Light-Sensitive 3-D Retinal Tissue
Researchers induced human stem cells to create a 3-D retina structure that responds to light. The finding may aid the study of eye diseases and could eventually lead to new therapies.
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