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Tuesday, October 21, 2014
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Correlation between the stem cells differentiation and topography of Zinc oxide nanorods
Newsha Kavosh, James Doonan, Joe Briscoe, Farahnaz Ansari, and Jeremy J. Ramsden

Since the conformation and symmetry may be equally important, we examine the order of nanorods on the surface to simulate the in vitro differentiation of stem cells and we revealed that stem cells respond differently to nanoscale features under the same conditions. Altering the orientation of nanotubular zinc oxide on the surface revealed changes in stem cell behaviour.

Mechanisms of beneficial effects of human placenta MSC transplantation in rats with experimental ischemic stroke
Yarygin K.N., Kholodenko I.V., Konieva A.A., Burunova V.V., Tairova R.T., Gubsky L.V., Cheglakov I.B., PirogovYu.A., Yarygin V.N., Skvortsova V.I.

Human MSC transplantation significantly reduced the volume of experimental ischemic lesion in rat model. It also greatly stimulated stem and progenitor cell proliferation in the subventricular region and hippocampus and cell migration from these areas towards the ischemia site. Beneficial effects of MSC in rats with brain ischemia are likely to be associated with enhancement of host neural stem and progenitor cell proliferation and migration towards the affected area.

Superporous SIKVAV-modified PHEMA scaffold promotes stem cell adhesion
V.Vanecek, S.Kubinova, D.Horak, V.Proks, E.Sykova

Poly(2-hydroxyethyl methacrylate) (PHEMA) is successfully used as a scaffold material for tissue engineering; however, it lacks functional groups that support cell adhesion. The laminin-derived peptide sequence SIKVAV is known to mimic the function of laminin, which is one of the biologically active proteins of the extracellular matrix. In this report, the adhesion of mesenchymal stem cells (MSC) to SIKVAV-modified PHEMA was investigated.

The effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling
M. Kapcalova, M. Babic, P. Jendelova, V. Herynek, K. Likavcanova, D. Horak, M. Hajek, E. Sykova

Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Patricia Ap. Santiago; Claudio A Suazo; Roberto C Giordano.

In biochemical processes involving cultivation of animal cells, the supply of oxygen in culture medium is an extremely important parameter in the project of bioreactors and its operation. In this work, the global volumetric transfer coefficient of oxygen (KLa) is evaluated in a Taylor vortex flow bioreactor (TVFB) and a correlation of mass transfer, of this equipment, is proposed.

Reliable and Predictive In Vitro Assays for Myelotoxicity and Cardiotoxicity of Kinase Inhibitors
Clarke E (1), Schwengberg S (2), Kettenhofen R (2), Dos Santos G (1), Bohlen H (2)

Kinase inhibitors (KIs) represent a new class of rationally designed drugs. The success of Imatinib has prompted the development of other KIs for the treatment of various cancers and inflammation. Although more successful than conventional therapies, myelotoxicity and cardiotoxicity are often major side effects of KIs. In order to predict if newly developed molecules demonstrated significant myelotoxicity or cardiotoxicity, we assessed a number of TKIs using in vitro models.

Intra-operative Bone Marrow Processing for Bone Regeneration
E. Nedelcu MD, A. Jamali MD, L. Hill RN, J. Nolta PhD, D. Vierria RN, M. Hoze RN, D. Taylor MD PhD, C. Gresens MD, D. Dwyre MD

Concentrated stem cell products obtained from autologous bone marrow aspirate were previously shown to regenerate avascular necrosis of the bone and non-union fractures. The aspirate processing was performed using apheresis technology, however, a detailed protocol has not been published yet. The aim of our study was to develop a clinical protocol using the CobeSpectra apheresis device to process the bone marrow aspirate.

The Expression and Activity of MMPs during Zebrafish (Danio rerio) Development
N.D. Harris, D.H. Li, J.Y. Keow, C. Po, A. Hong, K. Herrmann, B.D. Crawford

Recent advances have made the zebrafish an attractive system for studying MMP activity. However, there are few commercially available antibodies against MMPs that are suitable for studies using zebrafish. The objectives of the study presented in the poster were to develop effective immunological reagents for the study of MMPs in zebrafish and to test commercially available narrow-spectrum fluorogenic MMPs substrates in in vivo zymography.

Genetic profile of human embryonic stem cells (hESC) grown under different O2 concentrations
Sonia Prado, David Montaner, Dario Melguizo,Rubén Moreno, Joaquín Dopazo and Miodrag Stojkovic.

The development of mammalian embryos during the early stages takes place in a hypoxic environment. After 11 weeks of pregnancy the mother’s blood begins to flow freely in the placental space increasing the partial pressure of oxygen [1-3]. Therefore, we hypothesized that in vitro growth of hESC in normoxic conditions (21% O2) may change the profile and differentiation potential of hESC.

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Showing Results 41 - 50 of 70
Scientific News
Lab-developed Intestinal Organoids form Mature Human Tissue in Mice
Study produces unprecedented model to study intestinal diseases.
Personalized Cellular Therapy Achieves Complete Remission in 90 Percent of ALL Patients Studied
University of Pennsylvania and Children's Hospital of Philadelphia studies reveal unprecedented results with investigational therapy made from patients' own immune cells.
Researchers Develop New Cells Meant to Form Blood Vessels
A technique to jump-start the body's systems for creating blood vessels for the treatment of peripheral artery disease.
From Stem Cells to Billions of Human Insulin-producing Cells
Giant step toward new diabetes treatment.
Adaptimmune Announces Interim Results from Pilot Trial of NY-ESO T Cells
Study reports encouraging response rate and safety profile.
Positive Safety Results for Macular Degeneration Treatment
Phase 1/2 clinical trials of RPE cells for the treatment of dry age-related macular degeneration and Stargardt’s macular degeneration show positive long term safety results and signs of visual improvement.
Study Finds Link Between Neural Stem Cell Overgrowth and Autism-like Behavior in Mice
UCLA researchers demonstrates how, in pregnant mice, inflammation can trigger an excessive division of neural stem cells.
One Signal Means Different Things to Stem Cells Versus their Progeny
Results offer new insights into the regulation of stem cells and the process that leads to fully differentiated cells.
New Clues For Early Colorectal Cancer Detection
Study identifies new biomarkers which could help detect colorectal cancer.
Scientists Sniff Out Unexpected Role for Stem Cells in the Brain
NIH scientists find that restocking new cells in the brain’s center for smell maintains crucial circuitry.
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