Nonviral and non-integrating minicircle (mc) DNA technology available as well as a Human mc-iPS Cell Line
The minicircle DNA features easy-to-transfect molecules that have an extended expression lifespan in cells to efficiently reprogram somatic cells to the pluripotent state. After 21 days, the non-integrating mc-DNAs disappear and the iPS cells are fully reprogrammed. SBI offers the pre-made, ready-to-transfect 4-in-1 minicircle reprogramming DNA as well as the Human mc-iPS Cell line highlighted in Nature Methods, A nonviral minicircle vector for deriving human iPS cells. Jia F, et al., 2010 Mar;7(3):197-9. The mc-iPS Cell Line was derived from adult human adipose stem cells (hASCs).
Common Cell Transformed into Master Heart Cell By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.Improving Regenerative Medicine Lab-created stem cells may lack key characteristics, UCLA research finds.Muscles on-a-Chip This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.3-D Printed Lifelike Liver Tissue for Drug Screening A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling. Therapeutic Approach Gives Hope for Multiple Myeloma A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.Cat Stem Cell Therapy Gives Humans Hope By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives. Bile Acid Supports Production of Blood Stem Cells A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.New Biomarker to Assess Stem Cells Developed A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.Tricked-Out Immune Cells Could Attack Cancer New cell-engineering technique may lead to precision immunotherapies.Edited Stem Cells Offer Hope of Precision Therapy for Blindness Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.