Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


Qtempo

Product Description
Cardiac ion channels function in a sequential and interactive manner to drive the beating of cardiomyocytes. QTempo is the only human pre-clinical functional assay that can capture the complexity of that process. The underlying idea is simple: We (1) generate clusters of spontaneously beating cardiomyocytes from human iPS cells, (2) place these beating cardiomyocytes in a well with electrodes to monitor electropotential, and (3) Measure the effect of compounds and drugs on the waveform.

From this simple idea, the QTempo assay allows analysis of the full range of ion channels. QTempo directly measures not only QT interval, but also a range of other cardiac action potential parameters (such as beat rate and the QRS complex). QTempo identifies compounds that affect Na, K and Ca ion channels and reflects their complex interactions.

Uses beating human heart cells:
* Identifies beat rate dependent effects
* Identifies compounds that change beat rate
* Covers all cardiomyocyte ion channels
* Screens non-ion channel factors
* Faster, cheaper and kinder than using animals
The cardiomyocyte clusters used in QTempo generate robust, consistent data over extended periods. This allows a wide variety of drug concentrations to be sequentially tested, increasing confidence in drug safety before further development.

ReproCELL’s QTempo assay is offered in a variety of formats to suit customer requirements. ReproCELL is licensed by iPS Academia (Kyoto, Japan) to use iPS technology in this assay.

In all our tests, including assays of cardiotoxic compounds not correctly identified by the hERG assay, QTempo has generated results in complete agreement with clinical findings.

Two key technologies developed by ReproCELL underlie QTempo. The first is a protocol for the differentiation of cardiomyocytes from both ES and iPS cells. Secondly, ReproCELL has developed novel protein-free media that maintain the cardiomyocytes whilst allowing stable measurement of electropotential.
Product Qtempo
Company ReproCell Products
Price Request a quote
More Information View company product page
Catalog Number RCESD005
Quantity Unspecified
Company Logo

ReproCell Products
Reprocell Inc KDX Shin-yokohama 381 Bldg 8F 3-8-11, Shin-yokohama, Kohoku-ku, Yokohama Kanagawa 222-0033, Japan

Tel: +81 45-475-3887
Fax: +81 45-474-1006
Email: info_repro@reprocell.com



Scientific News
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Heart Defect Prediction Technology Could Lead to Earlier, More Informed Treatment
Experimental method uses genetics-guided biomechanics, patient-specific stem cells.
Immune Cells Remember Their First Meal
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases.
Cancer Cells Coordinate to Form Roving Clusters
Rice University scientists identify ‘smoking gun’ in metastasis of hybrid cells.
Bio-Mimicry Method For Preparing & Labeling Stem Cells Developed
Method allows researchers to prepare mesenchymal stem cells and monitor them using MRI.
Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
New Bio-Glass Could Make it Possible to Re-Grow or Replace Cartilage
Researchers at Imperial College London have developed a material that can mimic cartilage and potentially encourage it to re-grow.
Stem Cell Advance Could Be Key Step Toward Treating Deadly Blood Diseases
UCLA scientists get closer to creating blood stem cells in the lab.
Harnessing Engineered Slippery Surfaces For Tissue Repair
A new method could facilitate the transfer of intact regenerating cell sheets from the culture dish to damaged tissues in patients.
Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models
First direct experimental proof of causal effect, researchers say.

SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!