Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Join | Sign in
Home>Videos>This Video
  Videos

Return

Using Next-Gen Sequencing to Uncover Patterns of Allele-Specific Expression
University of California

Allelic imbalance refers to the unequal expression from maternal and paternal chromosomes of non-imprinted genes and has been shown to be a genome-wide phenomenon. Allelic imbalance can now be accurately measured by analyzing abundance of coding heterozygous SNPs from RNA sequencing and can range from 1:2 to more than 1:64; yet the mechanisms involved are not completely understood. In my presentation I will discuss data from next generation sequencing of CD4+ T cells from a pair of monozygotic twins discordant for the autoimmune disorder multiple sclerosis showing differential allelic expression in several genes. In many cases, the index variants are close to transcription factor binding sites in heavily methylated areas of the genome. However, the correlation with differential methylation patterns is not straightforward, thus suggesting a more complex regulatory mechanism is involved in allelic expression.

Request more information
Company product page


Access to this article and other content is for registered users.

Join the Technology Networks Community

  • Access to the latest scientific news, products and research through Technology Networks
  • Upload and share your posters on ePosters
  • View a library of 1,800+ scientific and medical posters
  • A library of 3,000+ scientific videos on LabTube


Sign In



Forgotten your details? Click Here
If you already have an account with Technology Networks, please use your existing login details. If you do not yet have an account please join here.

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Label-Free Binding Analysis Trends
Understand current trends and learn which application areas are expected to gain in popularity over the next few years.
‘Measuring Stick’ Standard for Gene Sequencing Now Available from NIST
New reference material, NIST RM 8398, to “map” DNA for genetic testing.
Single-cell Analysis Hits its Stride
Advances in technology and computational analysis enable scale and affordability, paving the way for translational studies.
Freshly Squeezed Vaccines
Microfluidic cell-squeezing device opens new possibilities for cell-based vaccines.
It Runs in the Family
Distantly related viruses share a common machinery for replication.
Scientists Create Mice with a Major Genetic Cause of ALS and FTD
NIH-funded study provides new platform for testing treatments for several neurodegenerative disorders.
New Target for Treating Rheumatoid Arthritis
Many affected individuals still suffer with progressive joint damage, despite treatment. This study has discovered a new treatment target which could open a door to preventing this ongoing damage.
Shining A New Light On The Immune System
Scientists at the University of St Andrews have developed a revolutionary method of identifying cells of the immune system with “molecular fingerprints” which could pave the way for the rapid detection of conditions such as leukaemia and lymphoma from a small blood sample.
Inexpensive Technique Developed to Manufacture Nanofibers
Current methods for producing nanofibers are incredibly costly and therefore limit accessibility, this new study opens the door to cheap, mass produced nanofibers.
Normal Skin Accrues High Number of Mutations Associated with Cancer
Researchers used genomic sequencing to gain insights into how somatic mutations build up in normal cells before the onset of cancer, a process that is poorly understood.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters