Corporate Banner
Satellite Banner
Technology Networks Header
Sunday, October 26, 2014
 
Register | Sign in
Home Page > Videos > In Silico Predictive Toxicology: Where are we at and Where are we Going?
  Videos

Return

In Silico Predictive Toxicology: Where are we at and Where are we Going?
Liverpool John Moores University

John Dearden, Emeritus Professor of Medicinal Chemistry Liverpool John Moores University

Abstract
In silico predictions of the toxicity of chemicals have the advantages of speed and cost, but accuracy needs to be improved. This is due, at least in part, to a shortage of good toxicity data on which to base in silico models. Much commercial software, and some free software, is now available for the prediction of numerous toxicity endpoints, and the performance of some of this software will be discussed. Attention is now focussing on mechanistic and toxicokinetic approaches, and on newer statistical methods, that will aid in silico prediction of toxicity. A recent book from our laboratory, edited by Mark Cronin and Judith Madden (In Silico Toxicology: Principles and Applications, RSC Publishing, 2010), brings all of this together, and more. The presentation will look in depth at two important endpoints, namely the human health endpoint skin sensitisation, and environmental toxicity as indicated by toxicity to the aquatic ciliate Tetrahymena pyriformis.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
If CD8 T Cells Take on One Virus, They’ll Fight Others Too
The findings suggest that innate immunity changes with the body’s experience and that the T cells are more versatile than thought.
IDT Shares Tips for Optimizing Target Capture
The article discusses improved target capture methods for increasing reliability of next generation sequencing data.
Earliest Modern Human Sequenced
Researchers discover fragments of Neandertal DNA in the genome of a 45,000-year-old modern human from Siberia.
Synthetic Biology On Ordinary Paper, Results Off The Page
By combining efforts and innovations, Wyss Institute scientists develop synthetic gene controls for programmable diagnostics and biosensors, delivered out of the lab on pocket-sized slips of paper.
NIH Begins Early Human Clinical Trial of VSV Ebola Vaccine
Human testing of a second investigational Ebola vaccine candidate is under way at the National Institutes of Health’s Clinical Center in Bethesda, Maryland.
Silencing the FOXP2 Speech Gene Causes Breast Cancer Cells to Metastasize
BIDMC investigators make the surprising discovery that a gene associated with speech and language is linked to advanced breast cancer.
Microscopic “Walkers” Find Their Way Across Cell Surfaces
Technology could provide a way to deliver probes or drugs to cell structures without outside guidance.
Fast Modeling Of Cancer Mutations
New genome-editing technique enables rapid analysis of genes mutated in tumors.
How Glands Expand To Fight Off Disease
UCL and Cancer Research UK demonstrate how specialised immune cells that patrol the body looking for signs of infection also trigger the expansion of glands called lymph nodes.
Magnesium Cuts Diabetes Risk
Only about half of Americans get the recommended daily amount in their diet.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv