Corporate Banner
Satellite Banner
Technology Networks Header
Monday, December 22, 2014
 
Register | Sign in
Home Page > Videos > Single Cell Expression profiling
  Videos

Return

Single Cell Expression profiling
TATAA Biocenter

Mikael Kubista, Professor, TATAA Biocenter

Abstract
There is surprisingly large variation in the copy number of transcripts among even seemingly like cells. Under most conditions for essentially all genes and tissues the variation among cells for any given transcript can be fitted quite well with a log normal distribution. The variation is caused by transcriptional bursting, which is a dynamic process expected to be correlated for genes critical for the same cellular process. This leads to correlated expression levels of related genes among individual cells. Most genes do not have correlated expression on single cell level and it makes no sense normalizing single cell expression data to reference genes. Rather cells can be classified based on the correlated expression of important genes. In my talk I will show how such single cell expression correlation can be used to distinguish cells as well as cell subtypes. Finally, I show how to cope with genomic DNA background in expression profiling studies with the ValidPrime concept.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
New And Beneficial Function Of Endogenous Retroviruses In Immune Response Identified
ERV play a critical role in the body’s immune defense against common bacterial and viral pathogens.
Scientists Identify New and Beneficial Function of Endogenous Retroviruses
Researchers found that ERV play a critical role in the body’s immune defense against common bacterial and viral pathogens.
Cells Build 'Cupboards' To Store Metals
Lawrence Livermore researchers have discovered that cells of the alga Chlamydomonas Reinhardti build a “pantry” to store metal and maintain equilibrium.
Predicting Antibiotic Resistance
A common set of features appear to be responsible for the development of resistance to several types of antibiotics.
53 Approved Drugs that May Block Ebola Infection Identified
Compounds may keep virus from entering cells and could accelerate drug development.
Tailor-Made Cancer Treatments? New Cell Culture Technique Paves The Way
Technique grew cells from 73% of patients in the study, more than three times as effective as previous methods.
Non-Gluten Proteins as Targets of Immune Response to Wheat in Celiac Disease
The results were reported online in the Journal of Proteome Research.
New Research Unlocks a Mystery of Albinism
A team led by Brown University biologists has discovered the way in which a specific genetic mutation appears to lead to the lack of melanin production underlying a form of albinism.
Predicting Sepsis
Altered white-blood-cell motion in burn patients may warn of infection.
Study Finds Genetic Clue To Menopause-Like Condition In Young Women
NIH-funded research may also contribute to understanding normal menopause.
Scroll Up
Scroll Down
Skyscraper Banner
SELECTBIO Market Reports
LabTube - Videos for the Scientific Community
eposters - The Online Journal of Scientific Posters
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn