Satellite Banner
Technology Networks Header
Friday, July 25, 2014
 
Register | Sign in
Home Page > Videos > Strategic Applications of Flow Chemistry within Drug Discovery
  Videos

Return

Strategic Applications of Flow Chemistry within Drug Discovery
Pfizer, Inc.

Despite the significant growth of interest in Flow Chemistry, it is often challenging to integrate this into research programs. Given the fast paced nature of drug discovery, and the growing constraint on resources, it is important to recognize opportunites to utilize Flow Chemistry at times when it can bring the maximum benefit to the program under study. This talk will look at several scenarios where this has been implemented within Pfizer. Firstly, one of the key interests is the opportunity to rapidly expand into novel chemical space, which is important both from a proprietary and pharmacological properties standpoint. Development of robust flow methodologies with a particular focus on library generation offers a unique opportunity to do this. Secondly, one of the most significant advantages of working in Flow is the ability to work with hazardous reagents, and examples of this will also be presented. Finally, expediting compounds as they progress is enabled through use of Flow by simply “scaling out” processes as opposed to “scaling up”. This talk will touch on the interaction between medicinal chemistry and process chemistry, and look at some of the benefits of screening chemistries to make them more amenable to flow with this in mind.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Schizophrenia’s Genetic Skyline Rising
Suspect common variants soar from 30 to 108 - NIH-funded study.
UK Government Must Do More to Reduce Risk of vCJD Infection
Report recommends that UK Government commission a full assessment of the risks currently faced by the UK blood supply.
Future Directions of Forensic DNA Databases
With the great success of the use of forensic DNA databases, new challenges are emerging.
Current Developments in Forensic Interpretation of Mixed DNA Samples
It is of great significance to develop innovative experimental techniques and software appropriate for complex mixed DNA analysis.
Preparation of Phosphines Through C–P Bond Formation
This article reviews some of the most important C–P bond formation strategies, organizing them according to the hybridization of carbon in the newly formed C–P bond.
Simultaneous Determination of Six Flame Retardants in Water
The work aimed to develop an analytical procedure for the extraction and simultaneous determination of selected flame retardants.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
Transplanting Gene into Injured Hearts Creates Biological Pacemakers
Researchers develop first minimally invasive gene therapy procedure to treat heart rhythm disorders by transforming ordinary heart muscle cells into specialized rhythm-keeping cells, potentially eliminating future need for electronic pacemakers.
Common Gene Variants Account for Most Genetic Risk for Autism
Roles of heritability, mutations, environment estimated - NIH-funded study.
Using LC-MS to Analyse Sulfonamides in Food Grade Honey
Sulfonamides are one of a number of groups of chemicals whose presence in honey is limited by international regulations.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv