Corporate Banner
Satellite Banner
Technology Networks Header
Wednesday, November 26, 2014
 
Register | Sign in
Home Page > Videos > Strategic Applications of Flow Chemistry within Drug Discovery
  Videos

Return

Strategic Applications of Flow Chemistry within Drug Discovery
Pfizer, Inc.

Despite the significant growth of interest in Flow Chemistry, it is often challenging to integrate this into research programs. Given the fast paced nature of drug discovery, and the growing constraint on resources, it is important to recognize opportunites to utilize Flow Chemistry at times when it can bring the maximum benefit to the program under study. This talk will look at several scenarios where this has been implemented within Pfizer. Firstly, one of the key interests is the opportunity to rapidly expand into novel chemical space, which is important both from a proprietary and pharmacological properties standpoint. Development of robust flow methodologies with a particular focus on library generation offers a unique opportunity to do this. Secondly, one of the most significant advantages of working in Flow is the ability to work with hazardous reagents, and examples of this will also be presented. Finally, expediting compounds as they progress is enabled through use of Flow by simply “scaling out” processes as opposed to “scaling up”. This talk will touch on the interaction between medicinal chemistry and process chemistry, and look at some of the benefits of screening chemistries to make them more amenable to flow with this in mind.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
New Advance in Cryopreservation Could Change Management of World Blood Supplies
Engineers have identified a method to rapidly prepare frozen red blood cells for transfusions.
New Study Reveals Why Some People May be Immune to HIV-1
Natural genetic variation in a protective antiviral enzyme holds promise for new therapies.
Antibiotic Resistance Threatens Future of Modern Medicine
Overuse and misuse of antibiotics, one of the key contributors to antimicrobial resistance (AMR).
Pain In A Dish
Turning skin cells into pain-sensing neurons.
How the Environment Contributes to Human Diseases
Using a new imaging technique, NIH researchers have found that the biological machinery that builds DNA can insert molecules into the DNA strand that are damaged as a result of environmental exposures.
Monitoring Effectiveness Of Hay Fever Immunotherapy
A new test for measuring histamine release from certain white blood cells could help doctors monitor the effectiveness of immunotherapy for hay fever.
Proteomics for Systems Toxicology
MS-based proteomics is maturing into a robust technology for the measurement of proteome-wide exposure effects.
How A Mutant Gene Can Cause Deafness
Scientists at The Scripps Research Institute (TSRI) have discovered how one gene is essential to hearing, uncovering a cause of deafness and suggesting new avenues for therapies.
Developing a Noninvasive Test for Endometriosis
UCSF researchers identify patterns of genetic activity that could help in early detection of disorder.
Precisely Off The Mark
Possible cause discovered for failure of targeted liver cancer therapies.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv