Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Join | Sign in
Home>Videos>This Video
  Videos

Return

BioAssay Ontology (BAO) and the LINCS Information FramEwork (LIFE) to Integrate and Analyze Diverse High Throughput and Cellular Profiling Assay Data
University of Miami

The lack of established and accepted standards to describe and annotate biological assays and screening results in the domain of high throughput and high content screening (HTS, HCS) is a severe limitation to utilize these valuable datasets to their maximum potential. We developed BioAssay Ontology (BAO:http://bioassayontology.org) to enable standardized description, integration and meta-­‐ analysis of various high throughput and profiling assay and screening results. BAO leverages Description Logic and Web Ontology Language to capture and formalize knowledge about assays and enable computational systems to utilize this knowledge. We illustrate our approach using data generated in the Library of Integrated Cellular Network-­‐based Signatures (LINCS) Program, a recent large-­‐scale systems biology data production and analysis effort funded by the NIH. Leveraging the ontology, we developed a semantic model to describe and integrate LINCS data. We implemented a semantic web software system, the LINCS Information FramEwork (LIFE:http://lifekb.org/) to exchange, query, and explore these datasets. Our approach facilitates the linking and classification of diverse entities, such small molecules, cellular model systems, diseases, gene and protein kinase targets, based on the underlying cellular profiling results.

Request more information
Company product page


Access to this article and other content is for registered users.

Join the Technology Networks Community

  • Access to the latest scientific news, products and research through Technology Networks
  • Upload and share your posters on ePosters
  • View a library of 1,800+ scientific and medical posters
  • A library of 3,000+ scientific videos on LabTube


Sign In



Forgotten your details? Click Here
If you already have an account with Technology Networks, please use your existing login details. If you do not yet have an account please join here.

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Diagnosing Cancer with Help from Bacteria
Engineered probiotics can detect tumors in the liver.
New Online Tool to Predict Genetic Resistance to Tuberculosis Drugs
New free online tool, TB-Profiler, analyses and interprets genome sequence data.
A Patient’s Budding Cortex — In A Dish?
Networking neurons thrive in 3-D human “organoid”
Expanding the Code of Life With New “Letters”
Researchers have developed a new nucleotide pair that can be added to DNA, raising the possibility that entirely new proteins could be created for medical uses.
Sperm Motility Gene Linked to Height
A team of scientists believe they have identified the association between human height and a specific gene found in sperm.
What Causes Immune Cell Migration To Wounds
Study shows triggers which lead immune cells to react and respond to wounded sites.
Imaging Test May Identify Biomarker of Alzheimer's Disease
Degeneration of the white matter of the brain may be an early marker of specific types of Alzheimer's disease (AD), including early-onset AD, according to results recently published.
Tumor Microenvironment Impacts Cancer Subtype Progression
Scientists report that two different mouse models of breast cancer progressed differently based on characteristics of the tumor microenvironment, which is the area of tissue in which the tumor is embedded.
Sistemic, RoosterBio Collaborate
This is a collaboration and memorandum of understanding to combine their technologies to advance mesenchymal stem/stromal (MSC) regenerative technology.
Scientists Win Grant to Expand Study of Innovative Obesity Therapy
The grant is to advance an innovative approach to the treatment of obesity, a serious health problem that affects more than one-third of all Americans.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters