Corporate Banner
Satellite Banner
Technology Networks Header
Wednesday, April 23, 2014
 
Register | Sign in
Home Page > Videos > Epigenetic Variation as a Driver of Breast Cancer Risk
  Videos

Return

Epigenetic Variation as a Driver of Breast Cancer Risk
Imperial College London

Genetic epidemiology aims to use the natural variation in the genome to look for associations between particular genotypes and disease risk or prognosis. Epigenetic epidemiology, a new area of research, aims to address the same questions about disease risk and prognosis using the natural variation present in the epigenome. It is now apparent that the variation between individuals does not occur at the classical promoter CpG island, but in other areas of the gene and that these regions are yielding markers of both cancer risk and prognosis. We have identified a breast cancer risk marker in the ATM gene using blood samples collected from prospective cohorts. We have also analysed blood samples from an ovarian cancer clinical trial, SCOTROC1, to identify prognostic biomarkers of progression free survival, overall survival, response and toxicity. Lastly, we have also shown that cancer risk exposures, such as smoking, can affect the epigenome detectable in blood DNA and may provide a more accurate measure of long term exposures. These studies, therefore, support the hypothesis that epigenetic variation may be a driver of cancer risk or prognosis.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Muscle Weakness Seen in Alcoholism Linked to Mitochondrial Repair Issues
Scientists found evidence that chronic heavy alcohol use affects a gene involved in mitochondrial repair and muscle regeneration.
Diagnosis of Bladder Cancer and Prediction of Survival by Urinary Metabolomics
Bladder cancer seems to be ideal for urinary metabolomics-based diagnosis, as urine can directly contact the cancer lesion in the bladder.
Gene Linked to Excess Male Hormones in Female Infertility Disorder
Discovery by NIH-supported researchers may lead to diagnostic test, treatment.
How a Silly Putty Ingredient Could Advance Stem Cell Therapies
The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become.
Domainex Programme Shows Great Promise for the Treatment of Inflammatory Diseases
Company’s IKKe/TBK1 programme to offer a disease-modifying treatment for COPD patients.
Nanocrystalline Cellulose Modified into an Efficient Viral Inhibitor
Researchers have succeeded in creating a surface on nano-sized cellulose crystals that imitates a biological structure.
Drug Does Not Improve Set of Cardiovascular Outcomes for Diastolic Heart Failure
NIH-supported study finds drug does appear to reduce hospitalizations for diastolic heart failure.
Will Forensic Biology Become Forensic Molecular Biology?
The article presents some examples of the potential for new molecular biology technologies to assist in the investigation of crime.
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
Unexpected Protein Partnership has Implications for Cancer Treatment
Scientists have identified a macrophage that works together in response to cancer drugs to increase inflammation in a way that may alter tumor growth.
Scroll Up
Scroll Down

Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv