Satellite Banner
Technology Networks Header
Friday, January 30, 2015
 
Register | Sign in
Home Page > Videos > Shaping the Epigenome by histone protein exchange and inheritance
  Videos

Return

Shaping the Epigenome by histone protein exchange and inheritance
Netherlands Cancer Institute

Epigenetic mechanisms of gene regulation and transcriptional memory are involved in normal development and disease. Our lab is combining the development of novel assays with genomics and proteomics approaches to unravel mechanisms of epigenetic regulation in budding yeast. Using a ‘genetic pulse-chase assay’ we monitor turnover and inheritance of histone proteins in budding yeast. We find that histones can be dynamic in non-replicating cells and are non-randomly inherited in replicating cells, putting constraints on models for epigenetic memory. Histone exchange and inheritance can influence the epigenome in many ways. To understand the biological significance of histone dynamics we are determining the connections with histone post-translational modifications. In addition, we are developing chromatin barcode screen to discover the genes and mechanisms involved in histone dynamics.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
New Method For Identifying Most Aggressive Childhood Cancers
A research group at Lund University in Sweden has found a new way to identify the most malignant tumours in children. The method involves studying genetic ‘micro-variation’, rather than the presence of individual mutations.
Powerful Tool Promises To Change The Way Scientists View Proteins
Aquaria, a publicly available web resource that streamlines and simplifies the process of gleaning insight from 3D protein structures, is fast, easy-to-use and contains twice as many models as all other similar resources combined.
“Unprecedented Sensitivity and Specificity” in Ovarian Cancer
Study of the use of the Parsortix system as a clinical application in the detection and treatment of ovarian cancer patients.
Nanoparticle Lights Up Artery-Clogging Plaque
A new imaging agent that may light up dangerous plaque in arteries is to be evaluated in a clinical trial.
Study Uncovers Range of Molecular Alterations in Head and Neck Cancers
TCGA tumor genome sequencing analyses offer new insights into the effects of HPV and smoking, and find genomic similarities with other cancers.
Beating The Clock: New Treatment For Rabies Developed
University of Georgia researchers have developed a new treatment for rabies.
New Cells May Help Treat Diabetes
UI group creates insulin-producing cells that normalize blood-sugar levels in diabetic mice.
NIH Launches Tool to Advance Down Syndrome Research
Web portal will help approved professionals to plan clinical studies.
Cancer-Causing Virus Blocks Human Immune Response
Epstein-Barr virus shown to outwit the human immune response using microRNAs.
Telomere Extension Turns Back Aging Clock In Cultured Cells
Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells. Cell proliferation capacity was dramatically increased, yielding large numbers of cells for study.
Scroll Up
Scroll Down
Skyscraper Banner
SELECTBIO Market Reports
LabTube - Videos for the Scientific Community
eposters - The Online Journal of Scientific Posters
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn