Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Videos>This Video
  Videos

Return

Shaping the Epigenome by histone protein exchange and inheritance
Netherlands Cancer Institute

Epigenetic mechanisms of gene regulation and transcriptional memory are involved in normal development and disease. Our lab is combining the development of novel assays with genomics and proteomics approaches to unravel mechanisms of epigenetic regulation in budding yeast. Using a ‘genetic pulse-chase assay’ we monitor turnover and inheritance of histone proteins in budding yeast. We find that histones can be dynamic in non-replicating cells and are non-randomly inherited in replicating cells, putting constraints on models for epigenetic memory. Histone exchange and inheritance can influence the epigenome in many ways. To understand the biological significance of histone dynamics we are determining the connections with histone post-translational modifications. In addition, we are developing chromatin barcode screen to discover the genes and mechanisms involved in histone dynamics.

Request more information
Company product page


Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Transporting Microscopic Cargo Between Human Cells
Scientists have developed a virus-inspired delivery system for material transport between cells.
Metabolite Promotes Cancer Cell Transformation
Researchers have identified a metabolite that promotes cancer cell transformation and colorectal cancer spread.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
Bird Flu Confirmed in the Netherlands
An outbreak of H5 avian influenza was confirmed in the Flevoland province of the Netherlands.
Turning Off Asthma Attacks
Researchers discover a critical cellular “off” switch for the inflammatory immune response that causes asthma attacks.
Zika’s Entry Points
Discovery shows Zika infection of neural progenitor cells occurs regardless of AXL production, which was thought to be the main vector for the virus.
New Strategy May Drop Cancer’s Guard
Scientists eye ways to deconstruct tumors’ protective wall with current diabetes drug.
Scroll Up
Scroll Down

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!