Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Videos>This Video
  Videos

Return

In Silico Predictive Toxicology: Where are we at and Where are we Going?
Liverpool John Moores University

John Dearden, Emeritus Professor of Medicinal Chemistry Liverpool John Moores University

Abstract
In silico predictions of the toxicity of chemicals have the advantages of speed and cost, but accuracy needs to be improved. This is due, at least in part, to a shortage of good toxicity data on which to base in silico models. Much commercial software, and some free software, is now available for the prediction of numerous toxicity endpoints, and the performance of some of this software will be discussed. Attention is now focussing on mechanistic and toxicokinetic approaches, and on newer statistical methods, that will aid in silico prediction of toxicity. A recent book from our laboratory, edited by Mark Cronin and Judith Madden (In Silico Toxicology: Principles and Applications, RSC Publishing, 2010), brings all of this together, and more. The presentation will look in depth at two important endpoints, namely the human health endpoint skin sensitisation, and environmental toxicity as indicated by toxicity to the aquatic ciliate Tetrahymena pyriformis.

Request more information
Company product page


Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Transporting Microscopic Cargo Between Human Cells
Scientists have developed a virus-inspired delivery system for material transport between cells.
Tissue Damage Is Key for Cell Reprogramming
Researchers have shown tissue damage is important for cells to return to an embryonic state for cell reprogramming.
Metabolite Promotes Cancer Cell Transformation
Researchers have identified a metabolite that promotes cancer cell transformation and colorectal cancer spread.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
Bird Flu Confirmed in the Netherlands
An outbreak of H5 avian influenza was confirmed in the Flevoland province of the Netherlands.
Pasteurised Bacterium Reduces Obesity and Diabetes
Researchers have discovered that an intestinal bacterium provides a lasting effect on the intestinal barrier.
Turning Off Asthma Attacks
Researchers discover a critical cellular “off” switch for the inflammatory immune response that causes asthma attacks.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!