Corporate Banner
Satellite Banner
Technology Networks Header
Friday, January 30, 2015
 
Register | Sign in
Home Page > Videos > Computational Analysis of Cancer Epigenome and Transcriptome
  Videos

Return

Computational Analysis of Cancer Epigenome and Transcriptome
Baylor College of Medicine

All Eukaryotic cells divide a finite number of times, termed replicative aging. Replicative aging in Saccharomyces cerevisiae is accompanied by decreased total histone protein levels. While genome profiling based on high throughput sequencing shows that nucleosome occupancy decreases 50% during replicative aging.  Most nucleosome positions are maintained during aging although their positioning becomes fuzzier, while other nucleosomes move to sequences predicted to better accommodate histone octamers. Transcriptome analysis reveals that all yeast genes are induced during aging, while  genes that are repressed in young cells are most induced, due to loss of unique nucleosome positioning patterns in promoters. Contrary to the loss of mitochondrial function during aging, mitochondrial DNA content increases significantly. Unprecedented levels of large-scale chromosomal alterations and increased retrotransposition were also observed during aging.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
New Method For Identifying Most Aggressive Childhood Cancers
A research group at Lund University in Sweden has found a new way to identify the most malignant tumours in children. The method involves studying genetic ‘micro-variation’, rather than the presence of individual mutations.
“Unprecedented Sensitivity and Specificity” in Ovarian Cancer
Study of the use of the Parsortix system as a clinical application in the detection and treatment of ovarian cancer patients.
Nanoparticle Lights Up Artery-Clogging Plaque
A new imaging agent that may light up dangerous plaque in arteries is to be evaluated in a clinical trial.
Study Uncovers Range of Molecular Alterations in Head and Neck Cancers
TCGA tumor genome sequencing analyses offer new insights into the effects of HPV and smoking, and find genomic similarities with other cancers.
Beating The Clock: New Treatment For Rabies Developed
University of Georgia researchers have developed a new treatment for rabies.
New Cells May Help Treat Diabetes
UI group creates insulin-producing cells that normalize blood-sugar levels in diabetic mice.
NIH Launches Tool to Advance Down Syndrome Research
Web portal will help approved professionals to plan clinical studies.
Cancer-Causing Virus Blocks Human Immune Response
Epstein-Barr virus shown to outwit the human immune response using microRNAs.
Telomere Extension Turns Back Aging Clock In Cultured Cells
Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells. Cell proliferation capacity was dramatically increased, yielding large numbers of cells for study.
Role of Immune System in Promoting Digestive Health
Study shows that the immune system helps to promotes digestive health by fostering community of “good” gut bacteria.
Scroll Up
Scroll Down
Skyscraper Banner
SELECTBIO Market Reports
LabTube - Videos for the Scientific Community
eposters - The Online Journal of Scientific Posters
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn