Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>Videos>This Video


Mass Spectrometry Imaging of Single Cells in Mouse Models of ALS
Brandeis University

Mass spectrometry (MS) is an indispensable technique in food safety, forensics, pharmaceuticals development, and in the detection of hazardous substances; and its use within the biological sciences is growing exponentially. Whereas traditional MS studies began with sample homogenization, recent technological advances have enabled imaging by mass spectrometry (MSI). Mass spectrometry requires the ionization (charging) of a sample, and this talk presents methods for improving the spatial resolution for ionization that employs lasers and a chemical “matrix” (Matrix-Assisted Laser Desorption Ionization-MALDI). Two novel techniques, both of which increase spatial resolution of MALDI imaging by ~10-fold and enabled the first analysis of single mammalian cells (neurons), will be presented. The first technique involves the simultaneous chemical fixation of tissues and deposition of matrix. The second technique involves the injection of a solution of MALDI matrix only upon cells of interest. Both techniques are compatible with fluorescence microscopy. The application of these techniques to the study of a mouse model of the neurodegenerative disease, Amyotrophic Lateral Sclerosis (ALS) is presented.

Request more information
Company product page

Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
New Analysis Technique for Chiral Activity in Molecules
Professor Hyunwoo Kim of the Chemistry Department and his research team have developed a technique that can easily analyze the optical activity of charged compounds by using nuclear magnetic resonance (NMR) spectroscopy.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Best Test to Diagnose Strangles in Horses Identified
New research by Dr. Ashley Boyle of New Bolton Center’s Equine Field Service team shows that the best method for diagnosing Strangles in horses is to take samples from a horse’s guttural pouch and analyze them using a loop-mediated amplification (LAMP) polymerase chain reaction (PCR) test.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
Lucentis Effective for Proliferative Diabetic Retinopathy
NIH-funded clinical trial marks first major advance in therapy in 40 years.
Antibiotics on Our Plates 'Could Lead to Health Catastrophe'
Two medical experts from The University of Queensland are urging China to curb its use of antibiotics in animals to avoid what could be a ‘major health catastrophe’ for humans.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Personalized Drug Screening for Multiple Myeloma Patients
A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos