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Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
The transcription factors that control YAP gene expression are unknown. This study demonstrates that ß-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene to drive YAP expression in CRC cells.
Cholinesterases, a Target of Pharmacology and Toxicology
This review’s main focus is on cholinesterases as targets of toxins and drugs. The biochemistry of AChE and BuChE is also discussed. Drugs and toxins are divided in chapters according to target sites.
Launch of DIRECT - An Innovative Medicines Initiative Project for Personalized Medicine in Diabetes
Academia and the pharmaceutical industry working together in the fight against diabetes.
Estimation of drug-metabolizing capacity by CYP-genotyping and CYP-expression
The lack of therapeutic effect of drugs or the appearance of undesired side-effects is partly caused by differences or changes in drug metabolism. This work aims to introduce an approach of combining CYP-genotyping and CYP-phenotyping tools to estimate patients’ drug-metabolizing capacity.
Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing
The gene silencing efficiency of mPEG-PLGA-PLL NPs is shown to be higher than that of commercially available transfecting agent Lipofectamine, while showing no cytotoxicity. The purpose of this work was to synthesize the novel biodegradable mPEG-PLGA-PLL NPs encapsulating siRNA, and examine the physical properties of NPs and in vitro siRNA release profile from NPs.
Study on Pivot-Point Vibration of Molecular Bond-Rupture Events by Quartz Crystal Microbalance for Biomedical Diagnostics
Molecular bond-rupture scanning is an effective method for the measurement of the energy level necessary to break a bond and distinguishing specific and nonspecific binding of biological molecules.
FDA Approves Gen-Probe's PROGENSA® PCA3 Assay
Company reveals first molecular test to help determine the need for repeat prostate biopsies in men who have had a previous negative biopsy.
An ice age flower 30,000 year old revived - resurrection of seed from permafrost
It was an Ice Age squirrel's treasure chamber, a burrow containing fruit and seeds that had been stuck in the Siberian permafrost for over 30,000 years. From the fruit tissues, a team of Russian scientists managed to resurrect an entire plant in a pioneering experiment that paves the way for the revival of other species.
NIH Common Fund Researchers Uncover Structure of Important Target for Drug Design
Researchers have uncovered a potent class of small molecules that selectively turn on the S1P1 receptor.
Two Decades of Studying Non-Covalent Biomolecular Assemblies by Means of Electrospray Ionization Mass Spectrometry
MS has evolved to impact a wide range of applications in structural biology. This paper charts some of the milestones in MS development as they pertain to the study of non-covalent complexes, and the novel applications they have enabled.
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Challenges for High Content Analysis of Infectious Diseases
Anne Danckaert, Institut Pasteur, speaking at Screening Europe 2011

The Potential of High Content Imaging in Primary Screening
Daniela Siebert, Novartis, speaking at Screening Europe 2011

Beyond Glucose: The Move Towards System Integration in Biosensors
Dr Jeff Newman, Cranfield University, speaking at Advances in Biosensors and Biodetection 2011.

Recent Advances in Detection and Biosensors
Professor Christopher R. Lowe, University of Cambridge, speaking at Advances in Biosensors and Biodetection.

Overcoming Technical Bias in Clinical Microarray Measurements
Professor Aron Eklund, Technical University of Denmark,speaking at Advances in Microarray Technology 2011.

Cancer Methylome Profiling using Methyl-DNA Capture
Dr Arjen Brinkman, Radboud University Nijmegen (NL), speaking at Next-Gen Sequencing Europe 2011.

A Systematic Investigation of Candidate Breast Cancer Progression-Associated Biomarkers Identified from Omic Screens: Leveraging Antibody-Based Proteomics
Prof. William Gallagher, Chief Scientific Officer at OncoMark, speaking at Advances in Microarray Technology 2011.

Hospital Integrated Biobanking and Prospective Cancer Biobanking (U-Can)
Anna Beskow, Director of Uppsala Biobank, speaking at World Biobanking Summit 2011.

Microfluidics Systems for Enhancing Life Science Applications Such as in situ Hybridization and in vitro Stem Cell Cultures.
Professor Martin Dufva, Technical University of Denmark, speaking at Lab-on-a-Chip.

Microfluidic “Apps” for Commercially Available Instruments
Professor Roland Zengerle, University of Freiburg, speaking at Lab-on-a-Chip 2011.

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