The Ras Pathway and Cancer: Regulation, Challenges and Therapeutic Progress
In normal health, Ras signaling is central to the regulation of intracellular signaling networks involved in cell proliferation, growth and survival. Like many cellular signaling pathways, however, the Ras-related cascade has a dark side. Mutations in the RAS gene itself, or in upstream or downstream regulators, can push the pathway into a constitutively active, cancer-inducing state.
Accurate Accounting of Corn Ethanol's Environmental Footprint
For the most accurate accounting of a product's environmental impact, scientists look at the product's entire life cycle, from cradle to grave of which greenhouse gas emissions are a key component. For corn ethanol, most greenhouse gas emissions can be mapped to the fuel's production, transportation, and combustion, but a large portion of the greenhouse gas calculation can be traced right back to the farm.
Landmark Field Trials Demonstrate the Potential of Gene-Editing
Researchers say gene editing technology has immense potential in facilitating crop improvement.
Brain Implant Shows Pain-Relieving Ability in Mice
A study has found that a computerized brain implant effectively relieves short-term and chronic pain in rodents.
New Type of Memory Identified by Behavioral Researchers
New research indicates the existence of an unconscious memory store that supports predictions made by one of the leading theories of consciousness, called the global workspace theory.
Risk Assessment and Expert Review of N-Nitrosamine Contaminants
In this article, David Elder discusses the identification of N-nitrosamine impurities in valsartan drug substances products in mid-2018 and highlights the regulatory response, sources of contamination and analytical methods used for identifying nitrosamines.
Eight Tips for Ensuring a Successful ELISA
Download this guide to learn more about how to ensure the success of your ELISA experiments.
Characterizing Structural Variants
Structural variants (SVs) are genomic variants encompassing insertions, deletions, duplications, inversions and translocations. SV analysis is of high importance for increasing our understanding of diseases including cancer, neurological disorders and rare genetic diseases. Using long nanopore sequencing reads, SVs can now be characterized with unprecedented resolution.
Accelerated Manufacturing of mRNA Vaccines
Accelerated timelines are critical when responding to an outbreak and efficient vaccine manufacturing is required to enable a quicker transition from research to the clinic, saving lives. mRNAs allow biotechnology companies to develop vaccines in response to pandemics, such as COVID-19, in a matter of weeks.
How To Study the Degenerating Brain
Download this listicle to discover more about some of the main techniques deployed to study the degenerating brain.
Quantitation in LC-MS
With growing concerns over a multitude of food risks, accurate and sensitive analytical tools are needed to ensure food safety. Liquid chromatography-mass spectrometry (LC-MS) has become an indispensable method for food safety testing and quality control, capable of detecting and quantifying even trace amounts of numerous contaminants and harmful species in food.