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timsTOF Pro - The new standard for 4D shotgun proteomics

Video

The timsTOF Pro powered by PASEF offers sequencing speed > 100 Hz without losing sensitivity or resolution. This is achieved by synchronizing the quadrupole isolation mass window with the elution time of the specific peptide packages from the TIMS funnel.

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Proximity Proteomics

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By joining forces and combining technologies in a new way, Harvard Medical School researchers have captured the first bird’s eye views of what happens at the molecular level when drugs, hormones and neurotransmitters activate certain kinds of cell receptors. Until now, scientists had been able to see only one part of the picture at a time.

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Top 5 Metabolomics News Stories of 2019

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We’ve seen some exciting developments in the metabolomics research field throughout 2019. This list details the top five most-read news stories, published on Technology Networks.

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E-cigarette Users Exposed to Levels of Metal Linked to DNA Damage
News

Researchers at the University of California, Riverside, have completed a cross-sectional human study that compares biomarkers and metal concentrations in the urine of e-cigarette users, nonsmokers, and cigarette smokers.

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From Facebook to DNA
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Computational biologists at Carnegie Mellon University have taken an algorithm used to study social networks, such as Facebook communities, and adapted it to identify how DNA and proteins are interconnected into communities within the cell nucleus.

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New Biomarkers for Diagnosis and Prognosis of Lung Cancer
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Research conducted in the SCBI of the UMA shows, using bioinformatic approaches, that the expression of repetitive DNA regions changes when healthy cells become cancerous. The researchers have identified new biomarkers for the diagnosis, prognosis and even treatment of lung cancer.

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Molecular Structure of Coronavirus Protein Marks "Critical" Step Towards Vaccine
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In a new study published in the journal Science, researchers outline their work that could be considered a major step towards the development of a viable vaccine for the 2019 novel coronavirus. The work was deemed so pertinent that the journal Science expedited its review process for the study manuscript.

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Dementia Protein Stops Tau Being Cleared From the Brain
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Researchers have identified a protein that increases the accumulation of neurotoxic tau tangles in the brain, which may pave the way to treatments that work by blocking this protein.

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How Cells Clear Misfolded Proteins From Tissues
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A team of researchers in Japan have discovered a system in which cells could capture, degrade and remove aberrant extracellular proteins.

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Disease Detectives: Working on the Frontline
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Throughout human history, we have always been at war with infectious agents. In the past, there used to be less sophisticated tools to identify epidemics. Nowadays, more advanced technologies, such as genomic sequencing, are being harnessed to gain information about infectious agents.

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Can Preprints Shake Up Biomedical Publishing?
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Academic publishing has proved stubbornly resistant to change, but preprint servers have started to make their mark. Technology Networks spoke to BiorXiv content lead Samantha Hindle to find out more about how preprints could shake up publishing and give research a new avenue to share their research.

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Weighing-up the Pros and Cons: Is There Proteomic Life Without Quantitative LC-MS?
Article

The technological developments and widespread acceptance of quantitative LCMS have become integral to the daily research of scientists – particularly to proteomics.

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Cancer Biomarkers: Powering Precision Medicine
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Researchers are developing biomarker tests to detect cancer early, monitor therapeutic efficacy and predict outcomes – making diagnosis and treatment more precise.

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Through the Art of Proteomics, Scientists Paint a Portrait of the Mouse Uterus
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Scientists from the Pacific Northwest National Laboratory (PNNL) recently published a study outlining their successful feat in mapping the proteome of the exceptionally small mouse uterus.

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Genetically Modifying Trees To Fight Climate Change
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Technology Networks spoke with Russell Monson, Professor of Ecology and Evolutionary Biology at the University of Arizona, to learn more about a recent study in which poplar trees were genetically modified to not harm air quality.

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