Genomic Atlas of the Human Proteome and Neurological Disorders

Understanding the tissue-specific genetic architecture of protein levels is instrumental to understand the biology of health and disease.

Here, we present the first multi-tissue study yielding hundreds of novel protein quantitative loci (pQTLs). This data will be instrumental to identify the functional gene from genome-wide association study (GWAS) signals, identify novel biological protein-protein interactions, identify novel potential biomarkers and drug targets for complex traits.

• A multi-tissue study which yielded hundreds of novel protein quantitative loci (pQTLs) in brain tissue, cerebrospinal fluid (CSF) and plasma from participants with and without Alzheimer's disease.
• The use of these pQTLs in the identification of risk genes from GWAS data.
• Potential drug targets for neurological diseases including Alzheimer’s disease.