Mass Spectrometry: From Imaging to Metabolic Networks

Poster

We show that network analysis of co-localized ions from mass spectrometry imaging data provides a detailed chemo-spatial insight into the metabolic heterogeneity of tumor. Furthermore, module preservation analysis between colorectal cancer patients with and without metastatic recurrence suggests hypotheses on the nature of the different local metabolic pathways.

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How to Tell “Fake” Olive Oils from the Genuine Article

Article

With olive oil’s popularity on the increase in recent years, olive oil production and sales have become big business. However, it also opens the industry up to fraudsters looking to profiteer from this trend. To tackle this problem, scientists have been exploiting differences at the chemical level to expose adulterated products.

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5 Trends in Mass Spectrometry

List

Mass spectrometry is an important tool for a multitude of research disciplines, from identifying toxins in food and beverages, diagnosing bacterial infections to imaging samples at the biomolecular level. In this list we will explore some of the exciting trends within the field of mass spectrometry and the applications that are exploiting these advances to move the technique forward.

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Algorithm Speeds Up Medical Image Analysis 1000 Times
Algorithm Speeds Up Medical Image Analysis 1000 Times
News

Medical image registration is a common technique that involves overlaying two images, such as magnetic resonance imaging (MRI) scans, to compare and analyze anatomical differences in great detail. Researchers have described a machine-learning algorithm that can register brain scans and other 3-D images more than 1,000 times more quickly using novel learning techniques.

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Scientists Discover Fundamental Rule of Brain Plasticity
Scientists Discover Fundamental Rule of Brain Plasticity
News

When one synapse strengthens, neighboring synapses weaken immediately based on the action of a crucial protein called Arc.

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Synaptic Threshold Mechanism Computes 'When to Escape'
Synaptic Threshold Mechanism Computes 'When to Escape'
News

How does your brain decide what to do in a threatening situation? A new paper describes a mechanism by which the brain classifies the level of a threat and decides when to escape.

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Bloodstains at Crime Scenes Can Now be Used to Determine Age of Suspect
Bloodstains at Crime Scenes Can Now be Used to Determine Age of Suspect
News

A new blood test, which could be performed at a crime scene, could help determine the age of a suspect or victim within just an hour.

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Penn Medicine Biochemist Receives Major Award for Research on Epigenetic Protein Modifications via Mass Spec
Penn Medicine Biochemist Receives Major Award for Research on Epigenetic Protein Modifications via Mass Spec
News

Benjamin A.Garcia, PhD, an expert in quantitative proteomics and Presidential Professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, has been awarded the Biemann Medal by the American Society for Mass Spectrometry (ASMS). The early-career award recognizes significant achievement in basic or applied mass spectrometry.

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Absence Epilepsy Seizures Visualized in the Brain
Absence Epilepsy Seizures Visualized in the Brain
News

Researchers took a closer look at the firing activity of neurons in an area of the visual cortex of a genetic mouse model of absence epilepsy.

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4 Considerations for Creating Standardized Cannabis Extracts
4 Considerations for Creating Standardized Cannabis Extracts
Article

Dosing and labeling are currently big issues for cannabis consumers and these results could help improve the quality and consistency of cannabis extracts.

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Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells
Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells
Article

Although cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.

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Case Study: Improve your lab’s efficiency and data compliance with a chromatography data system
Case Study: Improve your lab’s efficiency and data compliance with a chromatography data system
Article

In this Case Study, Peter Zipfell of Thermo Fisher Scientific explains how Broughton Laboratories, an analytical laboratory that supports method development and validation projects across pharma, implemented and upgraded a chromatography data system (CDS), increasing lab efficiency and improving data verification processes for overall time savings.

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The Ionic Basis for Electrosensation In Sharks and Skates
The Ionic Basis for Electrosensation In Sharks and Skates
Article

Neuroscientists have identified the ionic basis for electroreception in sharks and their relatives, skates.

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Cryo-EM and CX-MS: The Power Couple of Proteomics
Cryo-EM and CX-MS: The Power Couple of Proteomics
Article

An ambitious new workflow has married two cutting-edge proteomic analysis techniques to improve imaging of large protein assemblies. The combination of electron cryo-microscopy (cryo-EM) and cross-linking coupled mass spectrometry (CX-MS) allows deeper interrogation of protein structures to a level of detail that the techniques are incapable of obtaining on their own.

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Mass Spectrometry in Biopharmaceutical Discovery
Mass Spectrometry in Biopharmaceutical Discovery
Article

Biotherapeutics now makes up 25% of new drugs approvals. Their efficacy and safety are highly dependent on their structures, which are complex, heterogeneous and subject to modification. Advances in mass spectrometry are allowing more information on higher order structure and new imaging techniques are even providing insights into how biological drugs behave in vivo.

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