Latest Application Notes
Rapid and Reproducible Parallel Processing of Charge Heterogeneity Analysis of Protein Therapeutics
Rapid characterization of protein therapeutic charge variants can be challenging for the growing number and wider variety of new modality drug candidates. Automated capillary electrophoresis instruments offer fast separation times and high reproducibility for capillary isoelectric focusing.
Genome Integrity Analysis of Adeno-Associated Viruses (AAV) Using Multi-Capillary Gel Electrophoresis
An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells. This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases.
Acceleration of Method Optimization for AAV Capsid Purity Analysis
The purity of adeno-associated virus (AAV) capsid proteins has important implications for efficacy of the viral vector. A robust analytical method for assessment of the capsid purity for a range of serotypes that can provide reliable results in a timely fashion is desirable.
High-Throughput Multi-Capillary SDS Gel Electrophoresis of Proteins
Automated capillary electrophoresis instruments offer fast separation times and proven, high reproducibility for capillary sodium dodecyl sulfate gel electrophoresis (SDS-CGE), thus representing an excellent tool for the analysis of therapeutic proteins.
Microscale Separation: A Chromatography System for Low Volume Size Exclusion Chromatography
The structural characterization of complex proteins gives researchers a glimpse into their in vivo mechanistic functions and complex chemistries. In the case of drug development, structural information of proteins involved in disease pathways is crucial for downstream rational design of novel therapeutics.
A Simple Way to Set Up MALDI Imaging Measurements
MALDI Imaging is a powerful label-free technique that allows users to simultaneously examine different molecules in their native location from one tissue section. This technique combines the molecular depth obtained by mass spectrometry (MS) with the ability to spatially view the analytes on a cellular scale similar to microscopy.
Analyzing Raw Material for Oligonucleotide Synthesis
As the first step of the biopharmaceutical production process, the raw material of any synthesis needs to be analyzed thoroughly for the best quality products. The chemical synthesis of DNA oligonucleotides has been one of the enabling technologies for modern molecular biology.
Improve Your XL-MS Results
Proteins typically fold into well-defined tertiary structures and interact with other proteins to form homo- and hetero-oligomers to accomplish their physiological functions. These functions have implications on health and disease, but are also relevant for biotechnology applications.
Efficient and Automated 384 Well qPCR Set-Up
Setting up a qPCR is a tedious process consisting of multiple pipetting steps. One particularly challenging task is reformatting from microcentrifuge tubes into a 384 well plate, it is time consuming and requires a lot of concentration.
Extend the Life of Analytical Instruments and Columns
Download this app note to learn more about extending HPLC column life with good filtration, the long-term savings plus how you can protect the quality of your data.