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Latest Application Notes

Application Note

A Highly Robust and Sensitive Workflow for Quantifying RTP004 in Rat Serum

RTP004 is a proprietary peptide used by Revance Therapeutics as a novel excipient in DaxibotulinumtoxinA for injection. Due to its high molecular weight, high isoelectric point and strong non-specific binding property, the sample preparation and LC-MS method development for this peptide is very challenging.
Application Note

Microflow Chromatography: A Key to More Sensitive Metabolite Identification

In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Application Note

Pre-Clinical Quantification of Trastuzumab in Rat Plasma

In quantifying therapeutic peptides and proteins in biological matrices, traditional ELISA-only based techniques can suffer from high variability, narrow dynamic range, problems with selectivity and typically cannot use internal standards.
Application Note

Achieve Next Level Sensitivity for the Evolution of Routine Bioanalysis

Sample preparation and alternative chromatography techniques are often used to meet the sensitivity needs required in routine bioanalytical assays, but these methods can be time consuming.
Application Note

Cyclic Peptide Quantitation in Human Plasma

In biotherapeutic development, decreased drug doses and limited sample volumes require higher quantification sensitivity, while the complexity of biological matrices calls for the need of assay selectivity improvement.
Application Note

Bioanalysis of Small Molecule Pharmaceuticals Using Accurate Mass Spectrometry

Demands for improved sensitivity in routine bioanalytical assays continue to increase as drug discovery and development programs focus on more efficacious, lower dosage compounds. Pharma development scientists supporting this work therefore require highly sensitive and selective bioanalytical methods for quantification.
Application Note

DNA Purity Ratio

Many downstream experiments in molecular biology, such as next-generation sequencing, depend on the use of reasonably pure nucleic acid samples in adequate concentration ranges.
Application Note

Single Particle ICP-MS for Microplastic Detection

Unlocking Carbon-13 With Single Particle ICP-MS: Feasibility Study for Microplastic Detection
Application Note

Automated Protein Sample Preparation in Regulated Environments

Download this application focus to learn more about the benefits of automated sample preparation for drug development.
Application Note

Top Five Reasons To Consider Fully-Automated Enzyme Assays

Download this app note to discover reasons why you should consider fully automated enzyme analysis.
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