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Application Notes

 
Proteomic Interrogation of Primary Insulin-Secreting Pancreatic β-cells
Application Note

Dr Jarrod Marto’s lab from the Dana-Farber Cancer Institute have developed a new approach to identify expression of low-level enzymes for the first time in primary insulinsecreting beta cells (β-cells). In their research, they found that these proteins are critical, functional components of key metabolic pathways which can support β-cell survival under inflammatory stress.

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Improve Your Lab Workflow With an On-Site Gas Generator
Application Note

Peak Scientific develops market-leading nitrogen, hydrogen and zero air systems mainly for the fields of LC-MS. A Peak generator provides an easy to use gas solution without the safety concerns and managing of stocking and restocking supplies with frequent deliveries when using gas cylinders or other methods of bulk gas supply such as dewars.

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Two-Dimensional Isolation of Target Compounds From Complex Natural Products
Application Note

To date, mostly offline 2D-LC is used for two-dimensional purification, which is time-consuming, difficult to automate, and can incur sample loss or contamination. Download this app note to discover how online 2D-LC can help you overcome these issues.

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Vitamin D Biomarker Quantitation in Plasma: Improving Limits of Detection
Application Note

Vitamin D is widely monitored and used as an indicator for skeletal health in both children and adults with deficiencies resulting in rickets and osteoporosis. This app note details a simple extraction of OH-Vit D2 and OH-Vit D3 from human plasma.

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Annotation of Saponins in Chinese Medicines Using Structure-Based MS
Application Note

Despite possessing numerous advantageous pharmacological properties, the comprehensive annotation of saponins remains challenging. Download this app note to discover how a structure-based mass spectrometry workflow can be used.

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Handbook of ICP-QQQ Applications Using the Agilent 8800 and 8900
Application Note

In this application compendium, discover the true breadth of ICP-QQQ and how it can be applied for trace element analysis at low concentration, high reliability and high confidence.

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Highly Selective and Sensitive Method for Quantification of Nitrosamines in Valsartan Drug Substances
Application Note

Download this app note to discover a method for quantifying nitrosamine levels in sartans that is simple to carry out and has detection accuracy of at levels well below current FDA specifications.

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Comprehensive Profiling of Environmental Contaminants
Application Note

Download this app note to discover a high-resolution accurate mass GC/Q-TOF method to screen for environmental pollutants in water samples.

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A New Analytical Dimension for Improved Discrimination and Sensitivity in Detection of PFOS Pollutants
Application Note

Download this app note to discover a novel method to differentiate between various PFOS compounds that can increase identification confidence and sensitivity.

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µPAC™ capLC Columns: The Promise of Repeatability, Robustness, Throughput and Sensitivity for Proteomics Research
Application Note

Download this article to learn more about nanoLC-MS and capillaryLC-MS and the benefits of μPAC™ for proteomics research.

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