Latest App Notes & Case Studies

Formalin-fixed, paraffin-embedded (FFPE) tissue is a valuable resource in the retrospective proteomic analysis of clinical and non-clinical samples. However, sample preparation techniques typically involve laborious, time-consuming and potentially hazardous xylene-based deparaffinization steps.

Per-and polyfluoroalkyl substances (PFAS) are pervasive in our environment. Although they are found in a wide variety of household objects, they are associated with negative health effects. They can also be found in our drinking water.

Discover an automated solution for the consolidation and ranking of your metabolite structures. Explore a workflow that utilizes both EAD and CID data for the most confident characterization and streamlined data acquisition.

Discover an automated processing workflow that utilizes both EAD and CID data for the most confident characterization of pharmaceutical drug metabolites.

Protein-targeting chimeras (PROTACs) have gained significant attention recently due to their high potency in nanomolar drug concentrations and target selectivity. However, low test concentrations in complex matrices present analytical challenges.

Understanding the effects of in vitro drug metabolism is a key aspect of drug discovery and development. However, researchers must be able to make confident decisions quickly and easily.

Glucuronidation is an essential metabolic pathway for drug clearance and its characterization is crucial for optimizing the efficiency and safety of drug candidates.

Early ADME studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. Glucuronide conjugation is difficult to characterize using MS/MS alone, therefore fragmentation is also required to obtain structural information.

The scale of research into potential gene therapies often means that work is distributed across multiple locations. Investigators must have confidence that the results obtained at one site are consistent with results obtained at other sites participating in the study.

This app note presents a robust workflow that combines automated sample preparation, hydrophilic interaction chromatography and triple quadrupole mass spectrometry that can be applied to plasma and mammalian cell samples.