Latest App Notes & Case Studies
App Note / Case Study
How Syringe Filtration With Integrated Prefilter Technology Improves HPLC Performance and Throughput
In many laboratories, the need to consistently generate high -quality data means that managers, scientists and technicians must ensure their instruments are performing optimally around the clock.
App Note / Case Study
Separation of Isobaric Androgens Using MALDI-2 TIMS Imaging
In order to develop novel therapeutic treatments, it is key to understand the tissue-specific steroids metabolic pathways. Mass Spectrometry Imaging (MSI) is a powerful tool to visualize the distribution of such molecules involved in tissue metabolism.
App Note / Case Study
Rapid and Reproducible Parallel Processing of Charge Heterogeneity Analysis of Protein Therapeutics
Rapid characterization of protein therapeutic charge variants can be challenging for the growing number and wider variety of new modality drug candidates. Automated capillary electrophoresis instruments offer fast separation times and high reproducibility for capillary isoelectric focusing.
App Note / Case Study
Genome Integrity Analysis of Adeno-Associated Viruses (AAV) Using Multi-Capillary Gel Electrophoresis
An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells. This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases.
App Note / Case Study
Acceleration of Method Optimization for AAV Capsid Purity Analysis
The purity of adeno-associated virus (AAV) capsid proteins has important implications for efficacy of the viral vector. A robust analytical method for assessment of the capsid purity for a range of serotypes that can provide reliable results in a timely fashion is desirable.
App Note / Case Study
High-Throughput Multi-Capillary SDS Gel Electrophoresis of Proteins
Automated capillary electrophoresis instruments offer fast separation times and proven, high reproducibility for capillary sodium dodecyl sulfate gel electrophoresis (SDS-CGE), thus representing an excellent tool for the analysis of therapeutic proteins.
App Note / Case Study
Microscale Separation: A Chromatography System for Low Volume Size Exclusion Chromatography
The structural characterization of complex proteins gives researchers a glimpse into their in vivo mechanistic functions and complex chemistries. In the case of drug development, structural information of proteins involved in disease pathways is crucial for downstream rational design of novel therapeutics.
App Note / Case Study
A Simple Way to Set Up MALDI Imaging Measurements
MALDI Imaging is a powerful label-free technique that allows users to simultaneously examine different molecules in their native location from one tissue section. This technique combines the molecular depth obtained by mass spectrometry (MS) with the ability to spatially view the analytes on a cellular scale similar to microscopy.
App Note / Case Study
Analyzing Raw Material for Oligonucleotide Synthesis
As the first step of the biopharmaceutical production process, the raw material of any synthesis needs to be analyzed thoroughly for the best quality products. The chemical synthesis of DNA oligonucleotides has been one of the enabling technologies for modern molecular biology.
App Note / Case Study
Improve Your XL-MS Results
Proteins typically fold into well-defined tertiary structures and interact with other proteins to form homo- and hetero-oligomers to accomplish their physiological functions. These functions have implications on health and disease, but are also relevant for biotechnology applications.
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