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Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Application Note

Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry

Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Application Note

Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry

Biomolecules for therapeutic use must be stabilized in their active, native forms right
through to administration to the patient and delivery to their site of action. Stability
screening of biopharmaceutical formulations at an early stage helps ensure that further
investment is focused on those that demonstrate the best potential for further drug
development. Differential scanning calorimetry (DSC) is a technique that can be used
to rapidly determine optimum solution conditions for protein formulation stability,
helping to identify the best formulation candidates and accelerate development. This
application note describes Malvern MicroCal DSC technology and its use in formulation
development.
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