Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Application Note Nov 18, 2014
Malvern Instruments Limited
Biomolecules for therapeutic use must be stabilized in their active, native forms right through to administration to the patient and delivery to their site of action. Stability screening of biopharmaceutical formulations at an early stage helps ensure that further investment is focused on those that demonstrate the best potential for further drug development. Differential scanning calorimetry (DSC) is a technique that can be used to rapidly determine optimum solution conditions for protein formulation stability, helping to identify the best formulation candidates and accelerate development. This application note describes Malvern MicroCal DSC technology and its use in formulation development.