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Acceleration of Method Optimization for AAV Capsid Purity Analysis

The purity of adeno-associated virus (AAV) capsid proteins has important implications for efficacy of the viral vector. A robust analytical method for assessment of the capsid purity for a range of serotypes that can provide reliable results in a timely fashion is desirable. Multiple factors such as temperature and buffer concentrations affect the capsid protein stability which impacts the assembly of the capsids. Optimization of these parameters are needed in order to perform accurate evaluations. However, the analysis time for optimization of each parameter can be time consuming.

Download this app note to discover a solution that:

  • Is easy-to-use with new processing software that provides flexibility in viewing and reporting of data results
  • Offers optimized parameter settings
  • Uses a simple sample preparation procedure that completes in less than 1 hour