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Achieve Sensitive Quantitation of Signature Peptides With LC-MS

Peptides With LC-MS
Credit: iStock

Liquid chromatography-mass spectrometry (LC-MS) is a standard technique for the quantitative measurement of peptides and proteins in biotherapeutics development. However, mass spectrometry platforms such as time-of-flight (TOF) often lack sensitivity due to a loss of ion transmission between pulses .

This application note explores the latest quantitation methods, combining the accuracy of TOF systems with the sensitivity of microflow LC to exceed the lower limit of quantitation achieved with traditional high-flow LC. 

Download this application note to learn more about:

  • Low-level quantitation for increased confidence in your biotherapeutic workflow
  • Methods for greater selectivity, improved mass resolution and flexibility
  • Streamlined data management using integrated software

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