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Genome Integrity Analysis of Adeno-Associated Viruses (AAV) Using Multi-Capillary Gel Electrophoresis

An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells.This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases. AAV genome integrity analysis is a critical quality test, providing insights into transgene integrity and ensures product safety and efficacy.

Download this app note to discover a method that: 

  • Offers a quick assessment of AAV genome size purity with multiplex screening capability
  • Provides excellent separation resolution from partial AAV genomes and small size impurities
  • Is capable of analyzing the genome integrity of AAV samples of multiple serotypes or different genome sizes in one analysis