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GPC Characterization of Nylon using Formic Acid for Reduced Cost per Analysis

Gel permeation chromatography (GPC) or, equivalently, size-exclusion
chromatography (SEC) is a widely used technique to characterize a wide variety
of macromolecules, including, but not limited to commodity or bulk manufactured
polymers. This technique can be used to measure the molecular weight moments,
molecular weight distribution, the intrinsic viscosity, and/or hydrodynamic size of these
macromolecules.

While conditions that are both effective and practical have been determined for many
of these commodity polymers (i.e. THF for polystyrene, chlorinated benzenes for
polyolefins), some need further optimization in one aspect or another. This application
note describes one such polymer, nylon, where changes in operating conditions can
lead to improvements in both cost and health and safety.