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Light Scattering Methods for Better Developability Assessment of Biologic Therapeutics

The ultimate success of a biologic candidate can be impacted by the self-interaction of therapeutic proteins. During the development process, candidates are often assayed at concentrations that differ from that of the concentrations delivered to patients. Scientists need a way to assess how their biologics will behave once at clinical concentration using low amounts of material.

Read how scientists at Merck KGaA use light scattering measurements to predict how formulations will behave at clinically relevant concentrations and find the optimal formulation buffer for their biologics candidates.

Download this app note to learn how to:

• Use light scattering data to rank antibody candidates for improved downstream success

• Perform precise characterization of biologics with light scattering techniques

• Use combined thermal and colloidal stability studies to predict the behavior of antibody candidates