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Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography

A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities. Therefore, high-performance liquid chromatography is the method of choice if high-purity products are desired.

Download this app note to discover a purification workflow that: 

  • Can be performed with a high sample load
  • Ensures high reproducibility of shallow gradients typically employed for ON separation
  • Enables specific pooling of the fractions by purity