We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography
Application Note

Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography

Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography
Application Note

Purification of Single-Stranded RNA Oligonucleotides Using High-Performance Liquid Chromatography

A crucial step in any pharmaceutical production is the purification of the product. The purification of oligonucleotides (ONs) can be particularly challenging because of the high similarity of target and impurities. Therefore, high-performance liquid chromatography is the method of choice if high-purity products are desired.

Download this app note to discover a purification workflow that: 

  • Can be performed with a high sample load
  • Ensures high reproducibility of shallow gradients typically employed for ON separation
  • Enables specific pooling of the fractions by purity
Advertisement