Separation of Isobaric Androgens Using MALDI-2 TIMS Imaging
In order to develop novel therapeutic treatments, it is key to understand the tissue-specific steroids metabolic pathways. Mass Spectrometry Imaging (MSI) is a powerful tool to visualize the distribution of such molecules involved in tissue metabolism. However, the detection of androgens by mass spectrometry is a challenge, due to their low abundance and poor ionization efficiency. Decreasing the levels of circulatory androgens is a common technique to block tumor cell growth for the treatment of prostate cancer.
Download this app note to learn more about:
- Imaging of derivatized isobaric androgens
- Detecting endogenous concentrations of androgens
- Using trapped ion mobility to unravel complex isobaric features