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Strategies for Improving Protein Therapeutic Half-Life

Therapeutic Life

In the field of protein therapeutics, a protein-polymer conjugation strategy can improve the protein’s clinical potential by overcoming some of the challenges, such as physiochemical instability, immunogenicity and suboptimal circulation half-life. Knowing the molecular characteristics of a product is necessary to assess the success of a reaction and to optimize both the production process and the final product properties. 

This study aimed to understand the sample's constituents at the molecular level and assess the success of the PEGylation reaction to allow the scale-up of the reaction.

Download this app note to discover a solution that:

  • Allows for the direct calculation of the composition of the conjugated sample
  • Can characterize macromolecules in terms of absolute molecular weight, size and structure
  • Allows for a full and accurate characterization of a conjugated sample

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