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Use Of Microcalorimetry And Its Correlation With Size Exclusion Chromatography For Rapid Screening Of The Physical Stability Of Large Pharmaceutical Proteins In Solution

During the past two decades, there has been a rapidly increasing interest in development and commercialization of protein-based therapeutics. One of the greatest challenges during development for such products is the stabilization of proteins in solution.

The current studies were conducted to evaluate the use of microcalorimetry for rapid preliminary screening of pH stability and/or potential RTU solution formulations for two recombinant antibodies, Protein I and Protein II, each with molecular weights of approximately 150 kDa.