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Presence of host cell protein (HCP) contaminants in the final product, even at very low levels, may elicit unpredictable and serious immunogenic response in humans. The accurate detection, identification and quantification of HCPs during biotherapeutic development is thus critical in ensuring patient safety, and is a regulatory requirement.

This article explores the current state of play within the area of cancer proteomics, highlights some of the techniques used to investigate the proteome, and looks at the impact of combining proteomics with other ‘omics’ in relation to cancer research.

The accurate identification of bacterial infections is necessary for the fight against antibiotic resistance. This procalcitonin assay is set to aid antibiotic stewardship and improve healthcare outcomes for sepsis patients.

Antimicrobials have revolutionized medicine by enabling treatments for diseases that would once have proven fatal, however,they have since proven to be a double-edged sword.

Many recent advances in research have aimed to maximize the amount of data we can produce. But handling all that data is a challenge, and in analytical chemistry, data has more complexity and value than everyday spreadsheets, and tools matching that complexity will be needed to get data back into shape. We discussed how the field should approach these challenges with Andrew Anderson and , Graham McGibbon of Toronto-based analytical software supplier ACD/Labs.

A new device allows researchers to make lithium ion (Li-ion) batteries fail on demand, and that’s a crucial step in making them safer.

Non-invasive liquid biopsies are set to change the landscape of how cancers are diagnosed and treated in the future. We explore how mass spectrometry is helping researchers discover protein biomarkers in blood and urine, highlight challenges around their validation – and find out how close they are to reaching the clinic.

We recently spoke to Anton Toutov, Co-Founder and CSO at Fuzionaire, to learn how their radiolabeling platform can be used to improve disease diagnoses and drug discovery efforts. Anton touches on his professional background, his research on catalysis at Caltech, and how the discovery of a fundamentally new way to make and break molecular bonds can be applied to the diagnostics field.

Bacteriophage (phage) are obligate intracellular viruses that specifically infect bacteria. Here we take an overview of their structure, life-cycle and the role they have played in advancing science and medicine.

Personalized medicine isn’t all about our DNA. Researchers are increasingly looking past the information encoded on our genes to find answers to how individual variation contributes to complex disease. Companies like the Cambridge-based Microbiotica are much more interested in the bacterial cells that live inside us; our microbiome.