Advances in Fragment-Based Drug Discovery

Article   May 21, 2018 | by Laura Elizabeth Mason, Science Writer, Technology Networks

Advances in Fragment-Based Drug Discovery

Laura Mason

Science Writer



The Glycome and Cancer


The surfaces of cancer cells frequently express different types of glycoproteins, and because healthy cells don’t express these molecules (or do so at a much lower level), there has been significant interest in them as potential anticancer targets. Recent advances suggest we are about to see a resurgence in cancer glycomics.


Cisplatin Efficacy: The Importance of Measuring Uptake in Cancer Cells


Although cisplatin is clinically proven to combat numerous human cancers – bladder, head and neck, lung, ovarian, testicular – resistance to treatment remains a key challenge, and cisplatin patients can often relapse. Having the ability to determine the cellular uptake of cisplatin is key to developing novel strategies to increase tumor cell sensitivity to cisplatin.


Novel Collagen Membrane Improves Colon-on-a-Chip Functionality


A microfluidic model of the colon has been built using natural tissue base matrix, which closely mimics the structure and function of the colon.



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