mTOR signaling and autism

Latest research

1. 1. Biochemistry and Chemical Biology

   A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

   Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori

   An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
2. 1. Developmental Biology

   Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis

   Amandine Jarysta, Abigail LD Tadenev ... Basile Tarchini

   Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
3. 1. Neuroscience

   Experience transforms crossmodal object representations in the anterior temporal lobes

   Aedan Yue Li, Natalia Ladyka-Wojcik ... Morgan Barense
4. 1. Ecology

   Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

   Yang Ruan, Ning Ling ... Zhibiao Nan

   Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Convergent epigenetic evolution drives relapse in acute myeloid leukemia

   Kevin Nuno, Armon Azizi ... Ravindra Majeti

   Integrated analyses of acute myeloid leukemia genetics and epigenetics demonstrate that epigenetic evolution occurs in a convergent manner in the absence of DNA mutations at relapse post-chemotherapy.
6. 1. Genetics and Genomics
   2. Neuroscience

   Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

   Bohan Zhu, Richard I Ainsworth ... Javier González-Maeso

   Age and antipsychotic treatment effects on chromatin organization in the frontal cortex of schizophrenia subjects.
7. 1. Medicine

   Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

   Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown

   MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
8. 1. Medicine
   2. Cancer Biology

   RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

   Yang Liu, Yi Jiang ... Xi Gu
9. 1. Biochemistry and Chemical Biology

   Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

   George N. Bendzunas, Dominic P Byrne ... Natarajan Kannan
10. 1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action

    Ritwik Maity, Xuepei Zhang ... Javier Sancho