Empower Your Application-Specific Workflows With Automation
How To Guide
Published: April 3, 2025

Credit: Hamilton
From sample aliquoting to NGS library preparation and long-term sample storage - automation accelerates and standardizes every stage of your workflow, helping you achieve greater consistency, throughput and confidence in your results.
Automation is transforming how laboratories approach complex sample preparation and analysis, supporting higher reproducibility, improved data quality and enhanced efficiency across a wide range of applications.
Download this guide to explore:
- How automation technologies are driving advances in genomics, LC-MS sample preparation, biobanking and cell-based assay workflows
- Practical insights and success stories shared through case studies, webinars and videos
- Direct access to application-specific resources designed to support your automation goals
Automation Solutions for
Contents
Automation Solutions for
Genomics 3
LC-MS Sample Prep 5
Biobanking 7
Cell-Based Assays 9
1
Robotics - (Assay Ready) Workstations
Robotics - Customized Solutions and Modules
Storage - Automated Storage Systems
Off-Deck
3 7
2 5
-80°C -20°C to RT*
6
2
*Optional
5
3
4
1
8
4
7
8
4
6 5
Collect Blood
in Vacutainers
Primary Tube
Handling and
Aliquoting
Blood
Fractioning
Collect Saliva or
Buccal Swabs
Nucleic Acid (NA)
Extraction
Nucleic Acid
Quantification and
Normalization
(q)PCR Set-Up (q)PCR
NGS Library Prep Sequencing
Direct Label
and Stain Quantification
Optical
Genome
Mapping
*Sample Storage
(-80°C to RT*)
Quantification,
Normalization
and Pooling
Aliquot STARline
For sample aliquoting,
including capping and
de-capping of various
sample tubes
PCR Prep STARlet
For (q)PCR set-up
easyBlood STARlet
For image-based
detection and transfer
of fractioned blood
layers
FluorEye
Fluorescence reader
for on-deck sample
quantification SAM HD, BiOS®
, Verso®
Q-Series, Verso®
For automated sample storage from -80°C to (*)Room Temperature
NGS STAR V
for NGS library preparation with
cutting edge technology for highly
demanding protocols and high
throughput
NGS STARlet
For NGS library preparation of
high-priority samples. Also available
as an IVD-classified and certified
instrument: Clinical NGS STARlet
NGS STARline
For NGS library preparation
on our already successful (for
many years) Microlab®
STAR™
platform
Genomic STARlet
For silica membranebased NA extraction
using vacuum
MagEx STARline
For magnetic beadbased NA extraction
NIMBUS Prestoo
For magnetic beadbased NA extraction
and disk-based High
Molecular Weight
(HMW) DNA isolation
Long String STAR V
For magnetic diskbased Ultra-High
Molecular Weight
(UHMW) DNA isolation
and labeling
Hamilton Bonaduz AG
Europe HQ
Tel: +41 58 610 10 10
Hamilton Company
United States HQ
Tel: +1 775 858 3000
United Kingdom &
Ireland
Tel: +44 121 272 92 80
Spain, Portugal
Tel: +34 930 186 262
France
Tel: +33 184 008 420
Sweden, Norway,
Denmark & Iceland
Tel: +46 8410 273 73
Italy
Tel: +39 039 930 0606
Benelux
Tel: + 31 40 209 178 0
Germany, Switzerland,
Austria
Tel: +49 89 248 804 804
China
Tel: +86 21 6164 6567
Middle East (Dubai)
Dubai Science Park, UAE
© 2025 Hamilton Company. All rights reserved. All trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. First edition published in November 2023
Web: www.hamiltoncompany.com/automated-liquid-handling
HAMILTON'S ASSAY READY WORKSTATIONS COME WITH VERIFIED METHODS FROM:
DISCOVER HOW OUR CUSTOMERS LEVERAGE HAMILTON LIQUID HANDLERS TO OPTIMIZE THEIR GENOMIC WORKFLOWS
By incorporating Hamilton Automated Systems, numerous companies worldwide have witnessed substantial enhancements
in efficiency, accuracy, and productivity. This has enabled them to maintain a leading position in scientific research and
discovery. Discover selected stories that highlight how these companies have automated genomic workflows, the challenges
they faced, and the benefits they reaped on their path to streamlining their products and services with automation.
Visit Hamilton Robotics' Scientific Content Hub
where you will find a comprehensive collection of
field-focused content describing the latests trends
in automation within specific scientific areas.
Downloadable
Resources
Case Study
Webinar
Case Study
Webinar
Video
Case Study Webinar Case Study Webinar
Video Video
Automated Kit
Illumina TruSeq DNA
PCR-Free
Illumina TruSeq Stranded
Total RNA
Agilent’s SureSelect
Human All Exon V6
CeGaT Somatic Tumor
Panel
Illumina’s TruSight
Oncology 500
Twist Bioscience WholeExome Sequencing (WES)
Macherey Nagel NucleoMag
Pathogen kit for viral and
bacterial RNA/DNA from
clinical samples
Applied Biosystems TaqPath
COVID-19 CE-IVD RT-PCR
Kit
Seegene Allplex SARS-CoV-2
Assay
Multiple Kits Illumina DNA PCR-Free
Prep
Illumina TruSeq DNA
PCR-Free
Illumina TruSeq Stranded
Total RNA Gold with IDT
SOPHiA GENETICS DDM
Dx Hereditary Cancer
Solution
Country Germany United Kingdom South Africa South Africa, Israel,
United Kingdom
United Arab
Emirates Germany Italy
Automated
Workflow
NGS Library
Preparation
PCR/qPCR Plate
Set-Up
Nucleic Acid Extraction
Aliquoting/Blood
Fractioning
AUTOMATED WORKFLOWS LEGEND
Protein Enrichment/
Purification
Protein Enrichment Protein Purification
Buffer Exchange/
pH Adjustment
Buffer Exchange/
pH Adjustment
Protein Denaturation
and Digestion
Post-Translational
Modification
Analysis
Dye Removal
LC-MS
LC-MS
B C
D
E
E
H
G
G
F E
Clean up pH Adjustment
Enrichment/
Purification LC-MS
A E
Collect Blood
Collect Clear
Cell Lysate
Primary Tube Handling and Aliquoting
(Liquid)
Blood
Fractioning
(Dry Blood Spot)
Card Processing
2
3
Collect Saliva
or Urine
1
1 2
Solid-Phase
Extraction Liquid-Liquid
Extraction
Protein
Precipitation
B C D F
B
Desalting and
Concentration
3 4
4
5
5 5 5
IVDR 6 IVDR
6
SMALL
MOLECULES BIOLOGICS
Affinity Purification/Filtration
Protein Precipitation
Clear Vacuum
Station (CVS)
For purification or
filtration of samples using vacuum.
Functionalized Tips
For “in-tip” sample purification.
ODTC
For incubations
between +4 °C and
+99 °C.
Centrifuge
For spinning samples up to 4,200 rpm.
HHS
For heating up to 105
°C and shaking up to 2,500 rpm.
ApH
For pH measurement.
Scienova's Xpress
Dialyzer Plate
For “on-plate” buffer exchange.
[MPE]2
For solid-phase
extraction with
positive pressure.
A B C D E F G H
MODULES ASSAY READY
WORKSTATIONS
(Assay Ready) Workstations
Customized Solutions and Modules
Off-Deck
Aliquot STARline
For sample aliquoting,
including capping and
de-capping of various sample tubes.
easyBlood STARlet
For image-based detection and transfer
of fractioned blood
layers.
easyPunch STARlet
For automated
punching and processing of dry
samples on cards.
MassSTAR
For LC-MS sample preparation by protein precipitation.
(Dual) MassSTAR
For customizable
LC-MS sample
preparation.
STAR CL
For LC-MS sample preparation by protein precipitation.
DISCOVER HOW OUR CUSTOMERS LEVERAGE HAMILTON LIQUID HANDLERS
TO OPTIMIZE THEIR LC-MS WORKFLOWS
By using Hamilton Automated Systems, many companies around the world have
experienced significant improvements in efficiency, accuracy, and productivity. This has
allowed them to remain at the forefront of scientific research and discovery. Explore some
of the stories that showcase how these companies have automated LC-MS workflows, the
obstacles they encountered, and the advantages they gained as they streamlined their
products and services through automation.
Downloadable
Resources
Case Study
Webinar
Case Study
Webinar
Video
Case Study
Webinar
Video
Automated Kit or
Device Use
Chromsystems’
MassTox®
Immunosuppressants
Phenomenex StrataX-C 2 mg (SolidPhase Extraction
columns)
Thermo Scientific™
Rapid Equilibrium
Dialysis (RED) Plate
among others
Country Italy Germany United Kingdom
Automated Assay(s)
Immunosuppressants
for Therapeutic Drug
Monitoring
Drugs of Abuse
Testing
Plasma Protein
Binding, LogD,
Hepatocyte Stability
Visit Hamilton Robotics' Scientific Content Hub where
you will find a comprehensive collection of field-focused
content describing the latests trends in automation
within specific scientific areas.
Liquid Chromatography Mass Spectrometry
(LC-MS) Analysis for Drugs of Abuse Testing
Liquid Chromatography Mass Spectrometry
(LC-MS) for (Bio)pharmaceutical Research
If you're interested in learning more about LC-MS applications and streamlining
the process with automation, take a look at our collection of eBooks.
Liquid Chromatography Mass Spectrometry
(LC-MS) Analysis in Therapeutic Drug
Monitoring
© 2025 Hamilton Company. All rights reserved. All trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. Published in January 2024
Hamilton Bonaduz AG
Europe HQ
Tel: +41 58 610 10 10
Hamilton Company
United States HQ
Tel: +1 775 858 3000
United Kingdom &
Ireland
Tel: +44 121 272 92 80
Spain, Portugal
Tel: +34 930 186 262
France
Tel: +33 184 008 420
Sweden, Norway,
Denmark & Iceland
Tel: +46 8410 273 73
Italy
Tel: +39 039 930 0606
Benelux
Tel: + 31 40 209 178 0
Germany, Switzerland,
Austria
Tel: +49 89 248 804 804
China
Tel: +86 21 6164 6567
Middle East (Dubai)
Dubai Science Park, UAE Web: www.hamiltoncompany.com/automated-liquid-handling
Sample Collection &
Labelling Transport
Primary Sample
Processing
Fast Freezing &
Temporary Storage
Long Term
Storage
Sample Aliquoting
Aliquot STARline
For sample aliquoting,
including capping and decapping of various sample
tubes
easyBlood STARlet
For image-based
detection and transfer of
fractioned blood layers
SAM HD
For low/medium capacity
storage at -80 ºC
BiOS®
For large capacity
storage at -80 ºC
Verso®
For large capacity storage
between -20ºC and
ambient
Verso®
Q-Series
For low/medium capacity
storage between -20 ºC
and ambient
LabElite® Line
For capping and
decapping
of microtubes and
cryovials
Automation Solutions for
Genomic Workflows
Automation Solutions
for LC-MS Sample Prep
Workflows
For more information, take a look at our
dedicated flyers:
Labware
Sterile and non-sterile
tubes and sample racks
for efficient sample
storage
Downstream Sample
Processing
Registration
Sample Traceability - Sample Integrity - Sample Safety
EMPOWERING SCIENTISTS TO ACHIEVE MORE
Robotics - (Assay Ready) Workstations
Robotics - Customized Solutions and Modules
Storage - Automated Storage Systems
Off-Deck
© 2025 Hamilton Company. All rights reserved. All trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. Published in February 2024
Hamilton Bonaduz AG
Europe HQ
Tel: +41 58 610 10 10
Hamilton Company
United States HQ
Tel: +1 775 858 3000
United Kingdom &
Ireland
Tel: +44 121 272 92 80
Spain, Portugal
Tel: +34 930 186 262
France
Tel: +33 184 008 420
Sweden, Norway,
Denmark & Iceland
Tel: +46 8410 273 73
Italy
Tel: +39 039 930 0606
Benelux
Tel: + 31 40 209 178 0
Germany, Switzerland,
Austria
Tel: +49 89 248 804 804
China
Tel: +86 21 6164 6567
Middle East (Dubai)
Dubai Science Park, UAE Web: www.hamiltoncompany.com/automated-liquid-handling
DISCOVER HOW OUR CUSTOMERS LEVERAGE HAMILTON LIQUID HANDLERS AND STORAGE SOLUTIONS TO
OPTIMIZE THEIR BIOBANKING WORKFLOWS
By using Hamilton Automated Systems, numerous biobanks globally have witnessed notable enhancements in efficiency,
traceability, and productivity. This has enabled them to stay at the forefront of the industry. Explore some of their stories,
highlighting how these biobanks have automated workflows for sample processing and storage, the challenges they faced, and
the benefits they achieved by optimizing their offerings and services through automation.
Downloadable
Resources Case Study Case Study Webinar
Automated Workflow
Blood Blood and Bone Marrow Blood
Country Austria Germany -
Automated Systems Microlab®
STAR and STARlet,
Hamilton BiOS®
L9
Microlab®
STAR integrated with
a Hamilton LabElite Integrated
I.D. Capper, a Centrifuge, and a
Hamilton HMotion Plate Handler
Overview of Relevant Hamilton
Robotics and Storage Devices for
Biobanking
Visit Hamilton Robotics' Scientific Content Hub
where you will find a comprehensive collection
of field-focused content describing the latests
trends in automation within specific scientific
areas.
Sample Processing and Storage for Biobanking
If you're interested in learning more about
biobanking and streamlining the process
with automation, take a look at our eBook.
Sample Processing
Aliquoting
Sample Storage
AUTOMATED WORKFLOWS
LEGEND
Blood
Cell
Seeding
Media
Change
Passage/
Expansion
Cell Differentiation
/3D Formation
Live Cell Imaging
Sample
Preparation
Aliquoting Freezing & Storage
(liquid nitrogen)
Software-Controlled
Tip Position and
Immersion Depth
Automation Solutions for
Genomic Workflows
Automation Solutions for LC-MS
Sample Prep Workflows
For more information, take a look at our
dedicated flyers:
Analysis
Analysis
Twister Channel
and DeCapper
Tilt Module
Wide Bore Tips
Tip Boxes with Filter
Tips
Hamilton Heater
Shaker (HHS)
Liquid Dispenser
/Liquid Waste
Cell Care STAR
Integrated system for long-term cell culture maintenance
Cell
Seeding
Media
Change
Passage/
Expansion* (Compound)
Treatment
Cooled Carrier
Sample Cooling
Carrier
Hamilton Heater
Cooler
Heating Cooling
Module
S-Cap/V-Cap for
Air Filtration
Media Line
Robotics - (Assay Ready) Workstations
Handling and Pipetting Sterility Temperature Control Shaking Liquid Management
Robotics - Customized Solutions and Modules
Off-Deck
* optional off-deck cell counting
EMPOWERING SCIENTISTS TO ACHIEVE MORE
DISCOVER HOW OUR CUSTOMERS LEVERAGE HAMILTON LIQUID HANDLERS AND STORAGE SOLUTIONS TO
OPTIMIZE THEIR CELL-BASED ASSAYS
By using Hamilton Automated Systems, many laboratories have seen significant improvements in efficiency, reproducibility, and
minimized human error. Explore some of their stories, highlighting how they have automated workflows for cell-based assays,
the challenges they faced, and the benefits they achieved by optimizing their offerings and services through automation.
Downloadable
Resources Case Study
Case Study
Video
Webinar
Video
Type of Culture
Blood
Country Switzerland United Kingdom France
Automated Systems Microlab®
STARlet
Microlab®
STAR integrated with
an Automated Incubator and a
Plate Hotel, enclosed in a Class II
Safety Cabinet
Microlab®
Prep
Visit Hamilton Robotics' Scientific Content Hub
where you will find a comprehensive collection of
field-focused content, describing the latest trends
in automation, and within specific scientific areas.
© 2025 Hamilton Company. All rights reserved. All trademarks are owned and/or registered by Hamilton Company in the U.S. and/or other countries. Published in August 2024.
Cell-Based High-Throughput Screening
If you're interested in learning more about cellbased high-throughput screening and how to
streamline the process with automation, take
a look at our eBook.
2D Cell Culture
3D Cell Culture
Web: www.hamiltoncompany.com/automated-liquid-handling
Hamilton Bonaduz AG
Europe HQ
Tel: +41 58 610 10 10
Hamilton Company
United States HQ
Tel: +1 775 858 3000
United Kingdom &
Ireland
Tel: +44 121 272 92 80
Spain, Portugal
Tel: +34 930 186 262
France
Tel: +33 184 008 420
Sweden, Norway,
Denmark & Iceland
Tel: +46 8410 273 73
Italy
Tel: +39 039 930 0606
Benelux
Tel: + 31 40 209 178 0
Germany, Switzerland,
Austria
Tel: +49 89 248 804 804
China
Tel: +86 21 6164 6567
Middle East (Dubai)
Dubai Science Park, UAE
Brought to you by

Download the How To Guide for FREE Now!
Information you provide will be shared with the sponsors for this content. Technology Networks or its sponsors may contact you to offer you content or products based on your interest in this topic. You may opt-out at any time.
Experiencing issues viewing the form? Click here to access an alternate version