Selecting Analytical Solutions for High-Throughput Drug Discovery

Analytical solution for high-throughput drug discovery assays Learn more Selecting the right analytical technology to support drug discovery is a key decision This infographic compares different analytical technology in this space AEMS at a glance Obtain high quality data at speed Fast sample preparation time 1 sec Up to 1 sample per Data quality you can rely on (Low false positive/negative rate) Data acquisition time (30 min 1536 well plate)  2.5 nL Fast method development time Low consumable requirements Sample volume used  2.5 nL 5 - 50 μL 25 - 50 μL Acoustic ejection mass spectrometry Instrument purchase price Instrument size Sample preparation time Sample volume Consumable requirements and cost AEMS Solid phase extraction – mass spectrometry SPE – MS Plate Reader Don’t compromise Method development time False positive/negative rate 21- 38 sec per plate (6 to 1536 wells per plate) 10 mins (384 well plate) Approx. 8 sec per sample with SPE 30 min (1536 well plate) Data acquisition time High Low Medium Desirability score: Plate readers are well established for high throughput screening assays because they are cost-effective and have a favorable throughput for common assays. However, they require significant skill and method development time to select the optimum labelling-reagent, and the reagents themselves can be expensive. AEMS is more expensive to purchase but benefits from the specificity of mass spectrometric detection and the ability to measure a more diverse range of compounds. Being a label-free technique reduces the method development time and confidence in the accuracy of the results.