A Rapid uHPLC Method for the Simultaneous Determination of Drugs from Different Therapeutic Groups in Surface Water and Wastewater
News Feb 12, 2013
A SPE-UHPLC-UV method for the determination of 13 pharmaceuticals from different therapeutic groups in surface water and wastewater samples was proposed. The following three solid-phase-extraction (SPE) columns with polymeric sorbents were used as a pre-concentration step: the Oasis HLB (average recoveries 93.8 %), the Nexus (84.0 %) and the Bond Elut ENV (88.3 %). A reverse-phase UHPLC with a C(18e) monolithic column and gradient elution program was used to obtain the best separations for all 13 drugs in short analysis time (3.4 min). The LOD range for determined drugs was 0.02-0.18 μg L(-1), and the concentration range for drugs found in water samples was 0.06-0.90 μg L(-1). The proposed method was used to analyze different water samples, mostly from rivers, and can be used as a monitoring tool for environmental pollution.
The article is published online in the Bulletin of Environmental Contamination and Toxicology and is free to access.
The Friedrich Schiller University Jena Partners with ACD/Labs to Advance its Analytical Data Management StrategyNews
Implementation of ACD/Spectrus as an analytical data management system helps researchers and students streamline NMR and MS data processing, interpretation, collaboration, and training.READ MORE
Thermo Fisher Scientific Recognizes Tandem Mass Tag Grant Award Winners at ASMS 2018News
International competition rewards four top proteomics researchers for outstanding innovation and impact.READ MORE