Academics in the University of Surrey’s Department of Chemistry have developed a new diagnostic test for cocaine and benzoylecgonine (the main metabolite for cocaine) in urine and oral fluid.
For the first time, the researchers have been able to prove that it is possible to confidently detect levels of cocaine and their metabolites using a compact mass spectrometer. The test uses chromatography to separate cocaine from other compounds and can not only detect the presence of cocaine but also give quantitative data about the amount of cocaine a person has ingested.
The test was found to offer a level of sensitivity below the cut-off level normally used for oral fluid drug testing, meaning that it can detect even low levels of cocaine in a person’s urine or oral fluid. The technique potentially offers an effective solution for scenarios where a rapid test is required. This could include roadside testing by police of motorists, and also drug testing in the workplace and in prisons.
While there are a number of portable tests for cocaine commercially available, these are mainly based on antibody reagents, which cannot offer quantitative data and – since the cocaine antibody can bind to something that is not cocaine – can give false positive results.
The research paper’s lead author, Mahado Ismail of the University of Surrey, explained, “Surface mass spectrometry is used in a wide range of disciplines to obtain chemical information from the surface of a sample. However, until now it has not been possible to translate this method to low cost, portable testing.
"This new method, which extracts analytes from a surface and separates them using chromatography, has been shown to provide a sensitive, accurate result. Our next step will be to test the efficacy of the system for monitoring other drugs of abuse, while we are also looking for follow-on funding to further develop the test.”
Story from the University of Surrey. Original piece written by Ashley Lovell. Please note: The content above may have been edited to ensure it is in keeping with Technology Networks’ style and length guidelines.
Ismail, M., Baumert, M., Stevenson, D., Watts, J., Webb, R., Costa, C., … Bailey, M. (2017). A diagnostic test for cocaine and benzoylecgonine in urine and oral fluid using portable mass spectrometry. Analytical Methods. doi:10.1039/c6ay02006b