Detection of Gastric Cancer with FTIR Spectroscopy and Support Vector Machine Classification
News Sep 20, 2013
Early diagnosis and early medical treatments are the keys to save the patients' lives and improve the living quality. Fourier transform infrared (FT-IR) spectroscopy can distinguish malignant from normal tissues at the molecular level. In this paper, programs were made with pattern recognition method to classify unknown samples. Spectral data were pretreated by using smoothing and standard normal variate (SNV) methods. Leave-one-out cross validation was used to evaluate the discrimination result of support vector machine (SVM) method. A total of 54 gastric tissue samples were employed in this study, including 24 cases of normal tissue samples and 30 cases of cancerous tissue samples. The discrimination results of SVM method showed the sensitivity with 100%, specificity with 83.3%, and total discrimination accuracy with 92.2%.
The article is published online in the journal BioMed Research International and is free to access.
Response to New Illegal Drugs May be Expedited by Data-Sharing WebsiteNews
Scientists have launched a website where forensic chemists can share data on new drug variants, also called drug analogs. The NPS Data Hub (NPS stands for Novel Psychoactive Substances) includes the chemical structures of drug analogs and their chemical signatures, which are the keys to identifying them in the lab.READ MORE