FEI and NovAliX Partner
News Mar 22, 2016
FEI and NovAliX have announced a strategic partnership to enable NovAliX to provide commercial cryo-electron microscopy (EM)-based structural analysis services to its customers in the pharmaceutical and biotech industry. NovAliX has integrated a cryo-EM workflow based on a transmission electron microscope (TEM). The collaboration combines application, training, and support with on-site personnel from FEI.
“There is a growing demand for structural studies from the pharmaceutical industry, driven by the need for a deeper scientific understanding, and also because of stronger regulatory constraints. In the field of biologics, EM analysis has proven to be capable of delivering critical information for antibody selection, epitope mapping and formulation. As for small molecules research programs, cryo-EM can be uniquely valuable to obtain structural information on multi-protein complexes or membrane proteins, which is key to understanding the structure-function relationship,” said Denis Zeyer, CEO, NovAliX.
TEM-based structural analysis has emerged as an important complementary technique to traditional methods, such as X-ray crystallography and nuclear magnetic resonance (NMR). Although TEM lacks the atomic-scale resolution of those techniques, it can look at a broader range of structures under conditions much closer to the native intracellular environment. Zeyer added, “During the latest NovAliX conference, we have witnessed the interest and the relevance of biophysical tools in drug discovery.
So, this new offering will nicely complement our structural biology and biophysical platform that includes X-ray, NMR, surface plasmon resonance (SPR) and native mass spectrometry (native MS). Now with cryo-EM available, NovAliX scientists are able to deliver critical insights into the biology of protein complexes. Indeed, we will be able to fit X-ray structural results of individual proteins with a global structural view of the complex obtained by cryo-EM, which is otherwise not easily accessible.“
Peter Fruhstorfer, vice president and general manager of FEI’s Life Sciences Business states, “We are extremely pleased to be able to work with a leading contract research organization like NovAliX. The power and value of cryo-EM based structural analysis is evident from the quality of recent publications by academic and industry researchers. This collaboration with NovAliX is an important step in the broader commercialization and industrialization of the technology.”
I See What You're Thinking: Successful Image Reconstruction Using EEGNews
In a world first, scientists have been able to recreate images perceived by test subjects using only data from their EEG scans.READ MORE
Human Malaria Parasites Grown for the First Time in Dormant FormNews
One of the biggest obstacles to eradicating malaria is a dormant form of the parasite which is resistant to most antimalarial drugs and can reawaken years later, causing disease relapse. Researchers have shown they can grow the dormant parasite in engineered human liver tissue for several weeks, allowing them to closely study how the parasite becomes dormant, what vulnerabilities it may have, and how it springs back to life.READ MORE
Innovative Nanomaterial Made From Natural SubstancesNews
Protein nanofibres often have outstanding properties such as a high stability, biodegradability, or antibacterial effect. Artificially creating these fibres is not easy, much less assigning them specific functions. That and how fibres with new properties can be successfully created is now being reported by materials scientists in a new study.READ MORE