Freeze Drying Monitoring & Control

SP Scientific has entered into an exclusive agreement with Physical Sciences Inc. (PSI) to distribute the LyoFlux® 200 Water Vapor Mass Flow Rate Monitor for laboratory and pilot scale freeze dryers.

The LyoFlux® 200 is an innovative two line-of-sight tuneable diode laser absorption spectroscopy (TDLAS) based device for continuous monitoring of laboratory, pilot and production scale lyophilization cycles.

Operating in conjunction with SP Scientific’s LyoStar 3 development freeze dryer the LyoFlux® 200 enables users to better understand instantaneous changes in water vapor mass flow, and thus the sublimation rate for a given product during freeze-drying.

This is of particular importance for products processed in atypical container systems including syringes and PCR microplates.

The LyoFlux® 200 has also been shown to provide highly sensitive end point determination for both primary and secondary drying; continuous mass balance determination; real-time calculation of average product temperature and resistance as well as assessment of heat transfer coefficients for vials (Kv) or other containers. The LyoFlux® 200 can be used for performance testing and design space calculations on a freeze dryer.

Compact in design the LyoFlux® 200 can be installed and utilized on all sizes of developmental freeze dryers.