According to researchers, the results of their study illustrate the importance of intestinal bacteria's contribution to the operation of diet, metabolism and health interface.
Results were published in Scientific Reports magazine. The study was conducted at the University of Eastern Finland LC-MS-metabolomiikkakeskuksessa. The partners had a large number of Finnish and Swedish experts.
The study compared two groups who took part in a wider Diabetes Prevention study (DPS). Everyone had at the beginning of the study excess weight and impaired glucose tolerance. During 15 years of follow-up part of the ill with type 2 diabetes, some not. Differences between these two groups studied the unallocated metabolomics analysis. It can be studied to determine the metabolic profile of a concentration of a large number of metabolites rather than examining only a few of the predetermined marker.
The main differences with type 2 diabetes affected and unaffected metabolism profiles was observed at concentrations of the indole propionic acids and certain lipid metabolism products.
High serum concentration of the indole propionic acids were protected with diabetes illness. Indole propionic acids are intestinal bacteria metabolite. A generous use of whole grains, dietary fiber boosted its content. Indolipropionohapon a greater amount of the pancreatic beta-cell insulin secretion appeared to remain preferred, which may explain the protective effect.
Indole propionic contacting the risk of diabetes explained DPS material in addition to the two population-based study file, the file METSIM Finnish and Swedish VIP material. Also, there it turned out to be diabetes protective factor.
The study identified several new lipid metabolism products, with a high concentration was associated with improved insulin sensitivity and reduced the risk of diabetes. These metabolites content of the higher, the less of saturated fat diet. They, as well as the indole propionic acids, showed a high concentration of the protective body in low-grade inflammation of the farm.
- intestinal bacteria have been found in other studies to affect the risk of developing excess weight. In light of these results, the indole propionic acids may be one factor that mediates diet and intestinal bacteria a protective effect, academy researcher Kati Hanhineva says.
Direct determination of intestinal bacteria is difficult, so produced by the metabolism of intestinal bacteria intermediates assay may be useful in methods to examine the role of intestinal bacteria such as diabetes pathogenesis.
The DPS is the first randomized controlled lifestyle intervention study, which demonstrated that type 2 diabetes is preventable lifestyle changes in subjects with impaired glucose tolerance. Major lifestyle changes were weight loss, increased physical activity and a change in diet more in line with the recommendations of, for example, whole grain cereals, fruit and vegetables with respect to the use.
This article has been republished from materials provided by University of Eastern Finland. Note: material may have been edited for length and content. For further information, please contact the cited source.
de Mello, V. D., Paananen, J., Lindström, J., Lankinen, M. A., Shi, L., Kuusisto, J., ... & Bergdahl, I. A. (2017). Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports, 7.