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How Does the Black Widow Get Its Strength?

How Does the Black Widow Get Its Strength? content piece image
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Researchers at Northwestern University and San Diego State University (SDSU) have better unraveled the complex process of how black widow spiders transform proteins into steel-strength fibers. This knowledge promises to aid scientists in creating equally strong synthetic materials.

Black widow spiders and their relatives, native to temperate climates in North America, Europe, Asia, Australia, Africa and South America, produce an array of silks with exceptional materials properties.


Scientists have long known the primary sequence of amino acids that make up some spider silk proteins and understood the structure of the fibers and webs. Previous research theorized that spider silk proteins await the spinning process as nano-size amphiphilic spherical micelles (clusters of water soluble and non-soluble molecules) before being funneled through the spider’s spinning apparatus to form silk fibers. However, when scientists attempted to replicate this process, they were unable to create synthetic materials with the strengths and properties of native spider silk fibers. 


“The knowledge gap was literally in the middle,” Northwestern’s Nathan C. Gianneschi said. “What we didn’t understand completely is what goes on at the nanoscale in the silk glands or the spinning duct — the storage, transformation and transportation process involved in proteins becoming fibers.”


This “modified micelles theory” concludes that spider silk proteins do not start out as simple spherical micelles, as previously thought, but instead as complex, compound micelles. This unique structure is potentially required to create the black widow spider’s impressive fibers.


“We now know that black widow spider silks are spun from hierarchical nano-assemblies (200 to 500 nanometers in diameter) of proteins stored in the spider’s abdomen, rather than from a random solution of individual proteins or from simple spherical particles,” said Greg Holland,  co-corresponding author of the study and a professor at San Diego State University (SDSU). 


“One cannot overstate the potential impact on materials and engineering if we can synthetically replicate this natural process to produce artificial fibers at scale,” Gianneschi said.


"The practical applications for a material like this are essentially limitless," added Holland.

This article has been republished from materials provided by Northwestern University. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference
Lucas R. Parent, David Onofrei, Dian Xu, Dillan Stengel, John D. Roehling, J. Bennett Addison, Christopher Forman, Samrat A. Amin, Brian R. Cherry, Jeffery L. Yarger, Nathan C. Gianneschi, Gregory P. Holland. Hierarchical spidroin micellar nanoparticles as the fundamental precursors of spider silks. Proceedings of the National Academy of Sciences, 2018; 201810203 DOI: 10.1073/pnas.1810203115.