Labcyte Announces Collaboration with AstraZeneca
News Sep 25, 2013
Labcyte, who developed and commercialized acoustic liquid handling, recently developed techniques for the direct loading of samples into mass spectrometers. This capability creates the potential for high throughput, low cost, label-free analysis. AstraZeneca is supporting this development effort with the goal of expanding mass spectrometry-based analysis throughout the entire drug discovery and development process.
Mass spectrometry is used to quantify the amount of drug substance in screening assays, drug metabolism studies, and safety and efficacy experiments. The Labcyte Echo® acoustic liquid handling system uses sound waves to dispense a wide variety of liquids in nanoliter increments.
The development of an instrument that enables the delivery of test samples into a mass spectrometer through acoustic dispensing will generate better results with lower costs compared to traditional systems, which can be prone to transfer errors and sample contamination. It will streamline the process required to carry out these activities while increasing capacity to enable use in screening.
The drug discovery process requires continued advancement to generate greater biologically relevant data at lower costs and faster throughput. Data rich, label-free assays and broader phenotypic analyses are viewed as critical requirements to the future success of drug discovery programs. This trend requires novel techniques to meet these challenges. Mass spectrometry is an ideal candidate from a data perspective, but current throughput and cost per data point prevent the technology from being fully exploited. The goal of this collaboration is to overcome these limitations by enabling analysis of samples transferred directly from standard microplates with throughput significantly higher than current commercially available systems with substantially lower cost per data point.
“The potential for this breakthrough is yet another example of the incredible impact that acoustic dispensing is having in all areas of life sciences,” said Mark Fischer-Colbrie, Labcyte president and CEO. “Customers, including AstraZeneca, are using our acoustic liquid handling systems to discover new therapeutics, generate better diagnostic results or achieve personalized medical treatments. This work with AstraZeneca has the possibility to achieve dramatic improvements in measuring samples and experimental results. We are very excited to be working with one of the world’s leading pharmaceutical companies to pursue this major opportunity. It is a further testament to the unique capabilities of acoustic liquid handling.”
“The potential benefits of combining these technologies were originally identified by two of our Scientists,” said Mike Snowden, AstraZeneca VP Discovery Sciences. “We are excited to be working with Labcyte to develop acoustic dispensing for mass spectrometry. This project forms part of AstraZeneca’s efforts to access world-leading innovation to enhance the success of drug discovery. Combining acoustic delivery with mass spectrometry has the potential to open up new areas of science through transformational improvements in sampling rates and reductions in sampling volumes.”
Neuropeptide Y Y1 Receptor Structure Solved, Offers New Opportunities for Anti-obesity Drug DiscoveryNews
Scientists solve the crystal structure of Neuropeptide Y Y1 Receptor, offering new opportunities for anti-obesity drug discovery.READ MORE
Crystal Structure of Neuropeptide 1 Receptor Solved, Providing Therapeutic Angle For Obesity TreatmentNews
An international team has uncovered the potential to beat obesity at the cellular level, characterizing for the first time a complex, little-understood receptor type that, when activated, shuts off hunger.READ MORE
A Fatal AttractionNews
Malaria causes the bodies of its human hosts to emit specific odours from the skin that make the hosts even more attractive to mosquitoes, perpetuating transmission. Researchers have now identified the odours as organic hydrocarbons heptanal, octanal and nonanal, whose discovery could bring relief to a disease that claimed nearly half a million lives in 2016.READ MORE
Comments | 0 ADD COMMENT
World Congress on Advanced Biomaterials and Tissue Engineering
Jun 20 - Jun 21, 2018
29th International Conference on Public Mental Health and Neuroscience
Jul 16 - Jul 18, 2018